CAJ | 학술논문

目的:观察养血清脑颗粒联合盐酸氟西汀治疗卒中后抑郁的疗效.方法:68 例卒中后抑郁患者随机分组后分别接受养血清脑颗粒+盐酸氟西汀联合治疗(治疗组)和单纯盐酸氟西汀治疗(对照组),疗程为8 周;采用汉密尔顿抑郁量表(HAMD )进行评定.结果:在治疗8 周后,治疗组的显效率(48.7 %对47.1 %)和总有效率(79.4 %对76.5 %)与对照组相比均无显著差异,HAMD总评分和各项目评分也无显著差异.两组之间的睡眠障碍项目评分在第2 周时有显著差异(P<0.05 ),焦虑-抑郁情绪和躯体症状2 个项目评分在第2 周和第4 周均有显著差异(P<0.05 ).结论:养血清脑颗粒联合盐酸氟西汀治疗可改善卒中后抑郁的某些症状,优于单用盐酸氟西汀.
목적:관찰양혈청뇌과립연합염산불서정치료졸중후억욱적료효.방법:68 례졸중후억욱환자수궤분조후분별접수양혈청뇌과립+염산불서정연합치료(치료조)화단순염산불서정치료(대조조),료정위8 주;채용한밀이돈억욱량표(HAMD )진행평정.결과:재치료8 주후,치료조적현효솔(48.7 %대47.1 %)화총유효솔(79.4 %대76.5 %)여대조조상비균무현저차이,HAMD총평분화각항목평분야무현저차이.량조지간적수면장애항목평분재제2 주시유현저차이(P<0.05 ),초필-억욱정서화구체증상2 개항목평분재제2 주화제4 주균유현저차이(P<0.05 ).결론:양혈청뇌과립연합염산불서정치료가개선졸중후억욱적모사증상,우우단용염산불서정.
Objective: To observe the efficacy of Yangxueqingnao granule in combination with fluoxetine hydrochloride in the treatment of post-stroke depression (PSD). Methods: Sixty-eight patients with PSD were randomized to receive either Yangxueqingnao granule plus fluoxetine hydrochloride (treatment group) or fluoxetine hydrochloride alone (control group), and the duration of therapy was 8 weeks. The patients were evaluated with Hamilton Depression Scale (HAMD). Results: As compared with the control group, both the obvious effective rate (48.7 %versus 47.1 %) and total effective rate (79.4 %versus 76.5 %) after 8 weeks treatment in the treatment group had no significant differences. There were also no significant differences between the HAMD total score and each item score. There were significant differences in the item of sleep disorder score at week two between both groups (P<0.05); and there were significant differences between the item scores of anxiety-depression mood and somatic symptom at week 2 and 4 (P<0.05). Conclusions: Yangxueqingnao granule in combination with fluoxetine hydrochloride therapy may improve some symptoms of PSD, which is superior to fluoxetine hydrochloride alone.