中华损伤与修复杂志（电子版）
中華損傷與脩複雜誌（電子版）
중화손상여수복잡지（전자판）
Chinese Journal of Injury Repair and Wound Healing
2012年
2期
26-29
,共4页
糖尿病足%坏疽%危险因素
糖尿病足%壞疽%危險因素
당뇨병족%배저%위험인소
Diabetic foot%Gangrene%Risk factor
目的 探讨2型糖尿病患者糖尿病足合并坏疽的相关危险因素.方法 选取北京电力医院内分泌科、骨科、普外科收治的111例糖尿病足患者,根据糖尿病足Wagner分级标准分为2组,1～3级为非坏疽组,41例,4～5级为坏疽组,70例.回顾性分析、比较两组患者的临床特征及实验室检查结果,探讨坏疽的相关危险因素.结果 坏疽组患者炎症相关指标白细胞、中性粒细胞、纤维蛋白原及血沉明显高于非坏疽组患者.两组间年龄、糖尿病病程、糖化血红蛋白、总胆固醇、甘油三脂、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、血肌酐、白蛋白、血红蛋白、尿微量白蛋白及并发症高血压、脑梗死、心肌梗死、冠心病患病率间差异均无统计学意义(P＞0.05).坏疽组白细胞为(10.8±4.4)×109/L,中性粒细胞为(75±11)％；非坏疽组白细胞为(8.8±4.9)×I09/L,中性粒细胞为(70±14)％,两组比较P值分别为0031、0 016.坏疽组纤维蛋白原为(6.60±2.66)g/L,非坏疽组为(5 16±1 78)g/L,比值比(OR值)为0.465(95％ CI为0 173,1 248,P=0.028)；坏疽组血沉为(56±36)mm/h,非坏疽组为(36±27)mm/h,比值比(OR值)为1 109(95％ CI为1 020,1.215,P=0.015).结论 纤维蛋白原和血沉是糖尿病足合并坏疽的独立危险因素,提示感染是影响糖尿病足进展的重要因素,是糖尿病合并坏疽的独立危险因素.
目的 探討2型糖尿病患者糖尿病足閤併壞疽的相關危險因素.方法 選取北京電力醫院內分泌科、骨科、普外科收治的111例糖尿病足患者,根據糖尿病足Wagner分級標準分為2組,1～3級為非壞疽組,41例,4～5級為壞疽組,70例.迴顧性分析、比較兩組患者的臨床特徵及實驗室檢查結果,探討壞疽的相關危險因素.結果 壞疽組患者炎癥相關指標白細胞、中性粒細胞、纖維蛋白原及血沉明顯高于非壞疽組患者.兩組間年齡、糖尿病病程、糖化血紅蛋白、總膽固醇、甘油三脂、高密度脂蛋白膽固醇、低密度脂蛋白膽固醇、血肌酐、白蛋白、血紅蛋白、尿微量白蛋白及併髮癥高血壓、腦梗死、心肌梗死、冠心病患病率間差異均無統計學意義(P＞0.05).壞疽組白細胞為(10.8±4.4)×109/L,中性粒細胞為(75±11)％；非壞疽組白細胞為(8.8±4.9)×I09/L,中性粒細胞為(70±14)％,兩組比較P值分彆為0031、0 016.壞疽組纖維蛋白原為(6.60±2.66)g/L,非壞疽組為(5 16±1 78)g/L,比值比(OR值)為0.465(95％ CI為0 173,1 248,P=0.028)；壞疽組血沉為(56±36)mm/h,非壞疽組為(36±27)mm/h,比值比(OR值)為1 109(95％ CI為1 020,1.215,P=0.015).結論 纖維蛋白原和血沉是糖尿病足閤併壞疽的獨立危險因素,提示感染是影響糖尿病足進展的重要因素,是糖尿病閤併壞疽的獨立危險因素.
목적 탐토2형당뇨병환자당뇨병족합병배저적상관위험인소.방법 선취북경전력의원내분비과、골과、보외과수치적111례당뇨병족환자,근거당뇨병족Wagner분급표준분위2조,1～3급위비배저조,41례,4～5급위배저조,70례.회고성분석、비교량조환자적림상특정급실험실검사결과,탐토배저적상관위험인소.결과 배저조환자염증상관지표백세포、중성립세포、섬유단백원급혈침명현고우비배저조환자.량조간년령、당뇨병병정、당화혈홍단백、총담고순、감유삼지、고밀도지단백담고순、저밀도지단백담고순、혈기항、백단백、혈홍단백、뇨미량백단백급병발증고혈압、뇌경사、심기경사、관심병환병솔간차이균무통계학의의(P＞0.05).배저조백세포위(10.8±4.4)×109/L,중성립세포위(75±11)％；비배저조백세포위(8.8±4.9)×I09/L,중성립세포위(70±14)％,량조비교P치분별위0031、0 016.배저조섬유단백원위(6.60±2.66)g/L,비배저조위(5 16±1 78)g/L,비치비(OR치)위0.465(95％ CI위0 173,1 248,P=0.028)；배저조혈침위(56±36)mm/h,비배저조위(36±27)mm/h,비치비(OR치)위1 109(95％ CI위1 020,1.215,P=0.015).결론 섬유단백원화혈침시당뇨병족합병배저적독립위험인소,제시감염시영향당뇨병족진전적중요인소,시당뇨병합병배저적독립위험인소.
Objective To evaluate the related risk factors of diebetic foot with gangrene in type 2diabetes patients.Methods One hundred and eleven diabetic foot patients were divided into group gangrene (n=70) and group non-gangrene (n =41 ) based on diatetic foot wagner grading.The clinical data and laboratery test results related to gangrene were regression analysed.Results There were not significant differences between the two groups in glycosylated hemoglobin,total cholesterol,triglyeeride,high density lipoprotein cholesterol,low density lipoprotein cholesterol,serum creatinine,albumin,urinary albumin and hemoglobin.White blood cell [ ( 10.8 ±4.4) × 109/L vs.( 8.8 ±4.9) × 109/L,P =0.031 ],neutrophils [(75±11) ％ vs.(70±14)％,P=0.016],fibrinogen [(6.60±2.66) g/Lvs.(5.16 ±1.78)g/L,P =0.005 ] and erythrocyte sedimentation rate [ (56 ± 36) mm/h vs.(36 ± 27 ) mm/h,P =0.020) ] were higher in group gangrene than group non-gangrene,the odds ratio (OR) being 0.465 (95％ CI 0.173,1.248,P=0.028),1.109 (95％ CI 1.020,1.215,P=0.015) respectively.Conclusions Fibrinogen and erythrocyte sedimentation rate were the independent risk factors of gangrene,suggesting inflamation is the independent risk factor of gangrene in diabetic foot patients,and prevention and treatment of infection are very important in diabetic foot therapy.
