CAJ | 학술논문

目的探讨在手术中永久性植入125I粒子治疗脑瘤、肝癌、胆管癌、肺癌、直肠癌、前列腺癌及恶性畸胎瘤临床应用的安全性及疗效.方法回顾性分析38例经穿刺活检、组织学或细胞学检查确诊的肿瘤患者,采用治疗计划系统(TPS)重建肿瘤的三维图像,计算出粒子植入的数量和剂量分布曲线,125I粒子治疗肿瘤处方剂量为60～120 Gy,每例植入粒子6～40颗,中位粒子数为23颗.结果随访12个月,肿瘤完全缓解9例,部分缓解24例,无变化5例.12个月总有效率为86.8%.结论术中植入125I粒子治疗肿瘤是一种安全、有效的方法.
목적 탐토재수술중영구성식입125I입자치료뇌류、간암、담관암、폐암、직장암、전렬선암급악성기태류림상응용적안전성급료효.방법 회고성분석38례경천자활검、조직학혹세포학검사학진적종류환자,채용치료계화계통(TPS)중건종류적삼유도상,계산출입자식입적수량화제량분포곡선,125I입자치료종류처방제량위60～120 Gy,매례식입입자6～40과,중위입자수위23과.결과 수방12개월,종류완전완해9례,부분완해24례,무변화5례.12개월총유효솔위86.8%.결론 술중식입125I입자치료종류시일충안전、유효적방법.
Objective To investigate the safety and clinical efficacy of permanent implantation of125I radioactive particle in the urgery of malignancies such as brain tumors,liver cancer,cholangiocarcinoma,lung cancer,prostate cancer and malignant teratoma.Methods Thirty eight patients proved by puncture biopsy,his-tology or cytology were retrospectively analyzed.Three-D images of the tumor were reconstructed using treat-ment planning system (TPS),the number and the dose rate distribution of 125I seeds were calculated.The matched eripheral dose of 125I seeds implantation was 60～120Gy,the number of 125I seeds implanted ranged from 6～40 per lesion,and the median amount of implanted 125I seeds were 23.Results Twelve months followup after the therapy showed 9 cases of complete relief,24 cases of partial relief and 5 cases of no change.The overall effective rate(complete relief+partial relief) of 12 months was 86.8%.Conclusion Permanent implantation of 125I radioactive particle in the surgery of malignancies treatment is a safe,effective treatment for tumors.