中国医药
中國醫藥
중국의약
CHINA MEDICINE
2010年
9期
799-800
,共2页
原发性高血压%吡格列酮%厄贝沙坦%左心室肥厚%脑钠肽
原髮性高血壓%吡格列酮%阨貝沙坦%左心室肥厚%腦鈉肽
원발성고혈압%필격렬동%액패사탄%좌심실비후%뇌납태
Hypertension%Pioglitazone%Irbesartan%Left ventricular hypertrophy%Brain natriuretic peptide
目的 探讨吡格列酮对原发性高血压患者左心室肥厚及脑钠肽的影响.方法 原发性高血压伴左心室肥厚患者80例完全随机分成2组,各40例.常规治疗组给予厄贝沙坦(150 mg/d),吡格列酮组给予厄贝沙坦(150 mg/d)+吡格列酮(15 mg/d),均治疗6个月.比较2组治疗前后左心室质量指数(LV MI)、血清脑钠肽浓度的变化.结果 治疗后2组患者LVMI、血清脑钠肽浓度均下降(P＜0.05),2组治疗后比较,吡格列酮组LVMI、血清脑钠肽浓度下降为[(126.2±10.4)g/m2、(113.6±42.9)ng/L,较常规治疗组[分别为(135.5±11.2)g/m2、(138.8±45.8)ng/L]明显(P＜0.05).结论 吡格列酮能逆转高血压病患者的左心室肥厚,并降低血清脑钠肽浓度.
目的 探討吡格列酮對原髮性高血壓患者左心室肥厚及腦鈉肽的影響.方法 原髮性高血壓伴左心室肥厚患者80例完全隨機分成2組,各40例.常規治療組給予阨貝沙坦(150 mg/d),吡格列酮組給予阨貝沙坦(150 mg/d)+吡格列酮(15 mg/d),均治療6箇月.比較2組治療前後左心室質量指數(LV MI)、血清腦鈉肽濃度的變化.結果 治療後2組患者LVMI、血清腦鈉肽濃度均下降(P＜0.05),2組治療後比較,吡格列酮組LVMI、血清腦鈉肽濃度下降為[(126.2±10.4)g/m2、(113.6±42.9)ng/L,較常規治療組[分彆為(135.5±11.2)g/m2、(138.8±45.8)ng/L]明顯(P＜0.05).結論 吡格列酮能逆轉高血壓病患者的左心室肥厚,併降低血清腦鈉肽濃度.
목적 탐토필격렬동대원발성고혈압환자좌심실비후급뇌납태적영향.방법 원발성고혈압반좌심실비후환자80례완전수궤분성2조,각40례.상규치료조급여액패사탄(150 mg/d),필격렬동조급여액패사탄(150 mg/d)+필격렬동(15 mg/d),균치료6개월.비교2조치료전후좌심실질량지수(LV MI)、혈청뇌납태농도적변화.결과 치료후2조환자LVMI、혈청뇌납태농도균하강(P＜0.05),2조치료후비교,필격렬동조LVMI、혈청뇌납태농도하강위[(126.2±10.4)g/m2、(113.6±42.9)ng/L,교상규치료조[분별위(135.5±11.2)g/m2、(138.8±45.8)ng/L]명현(P＜0.05).결론 필격렬동능역전고혈압병환자적좌심실비후,병강저혈청뇌납태농도.
Objective To explore the effect of Pioglitazone on hypertension with left ventricular hypertrophy and brain natriuretic peptide. Methods Eighty cases of hypertension patients were selected and randomly divided into pioglitazone group and the conventional treatment group. Conventional treatment group were treated with irbesartan (150 mg/d) ; pioglitazone group were treated with irbesartan ( 150 mg/d) and pioglitazone ( 15 mg/d). Both treatment lasted for 6 months. The changes of the levels of left ventricular mass index (LVMI) , serum brain natriuretic peptide(BNP) were compared between two groups before and after treatment. Results The levels of LVMI,serum BNP decreased after treatment in the pioglitazone group and the conventional treatment group. There were significant differences before and after treatment (P < 0. 05). After treatment, the levels of LVMI, serum BNP decreased significantly in the pioglitazone group( P < 0.05). Conclusion Pioglitazone can reverse left ventricular hypertrophy and reduce serum concentration of brain natriuretic peptide.
