CAJ | 학술논문

目的研究蛋白激酶C(protein kinase C,PKC)一0在人脑膜瘤组织中的表达及其临床意义.方法采用免疫组化染色法对30例非侵袭性脑膜瘤和30例侵袭性脑膜瘤组织中PKCθ表达进行检测,分析与病理性质的关系.结果侵袭性脑膜瘤组织中PKCθ阳性表达率明显低于非侵袭性脑膜瘤组织,两者差异显著(P<0.05).结论侵袭性脑膜瘤组织中PKCθ表达下调,对脑膜瘤的发生和侵袭起作用.
목적 연구단백격매C(protein kinase C,PKC)일0재인뇌막류조직중적표체급기림상의의.방법채용면역조화염색법대30례비침습성뇌막류화30례침습성뇌막류조직중PKCθ표체진행검측,분석여병이성질적관계.결과 침습성뇌막류조직중PKCθ양성표체솔명현저우비침습성뇌막류조직,량자차이현저(P<0.05).결론 침습성뇌막류조직중PKCθ표체하조,대뇌막류적발생화침습기작용.
Objective To study the expression and clinical meaning of tight junctions protein regulator PKC θ in human meningioma tissue.Method The expression of PKC θ in 30 non-invasion and 30 invasion meningioma tissue is tested by using immunohistochemistry S-P method,with the goal of analyzing the relationship between the expression of PKC θ and pathology character.Results The positive rate ofPKC θ in invasion meningioma tissue is obviously lower than in non-invasion meningioma tissue.The difference is significant(P<0.05)Conclusions The lower expression of PKC θ in invasion meningioma tissue pmbably affects occurrence and invasion of the meningioma by ehang4ng the structure and function of TJs.