CAJ | 학술논문

目的通过检测血清中的EB病毒Rta/IgG抗体,评价其在鼻咽癌诊断上的价值.方法收集211例未经治疗的鼻咽癌患者,413例对照组(包括203例相似症状的非鼻咽癌病例和210例健康体检者)的血清,用酶联免疫吸附法(ELISA)检测Rta/IgG抗体.应用受试者工作特征(ROC)曲线对结果进行分析评价.结果鼻咽癌组的Rta/IgG抗体rA值中位数明显高于对照组(P<0.001).Rta/IgG抗体检测诊断鼻咽癌的ROC曲线下面积为0.933,最佳截断点时敏感度为90.5%,特异度为90.1%.结论采用ELISA方法检测血清中Rta/IgG抗体可以作为检测EB病毒的一个新指标,并可作为鼻咽癌诊断的重要标志物之一.
목적 통과검측혈청중적EB병독Rta/IgG항체,평개기재비인암진단상적개치.방법 수집211례미경치료적비인암환자,413례대조조(포괄203례상사증상적비비인암병례화210례건강체검자)적혈청,용매련면역흡부법(ELISA)검측Rta/IgG항체.응용수시자공작특정(ROC)곡선대결과진행분석평개.결과 비인암조적Rta/IgG항체rA치중위수명현고우대조조(P<0.001).Rta/IgG항체검측진단비인암적ROC곡선하면적위0.933,최가절단점시민감도위90.5%,특이도위90.1%.결론 채용ELISA방법검측혈청중Rta/IgG항체가이작위검측EB병독적일개신지표,병가작위비인암진단적중요표지물지일.
Objective This study was aimed to investigate the clinical value of Epstein-Barr virus (EBV) Rta/IgG in the diagnosis of ansepharyngeal carcinoma (NPC). Methods Serum samples derived from 211 untreated patients with NPC, 413 subjects including 203 non-NPC ENT patients and 210 healthy volunteers as control were examined for the presence of antibodies directed against Rts/IgG by using enzyme-linked immnunosorbent assay (ELISA). Receiver operating characteristic (ROC) curve was applied to perform methodical evaluation of this tumor marker. Results The rA value median of Rta/IgG in NPC group was significantly higher than one in control group (P < 0.001). The area under ROC was 0.933. The sensitivity and specificity of this marker were 90.5% and 90.1%, respectively, when the best cutoff value was defined. Conclusion Rta/IgG detected with ELISA method is a new target of EBV, and may be one of important marker for NPC diagnosis.