中华实验和临床病毒学杂志
中華實驗和臨床病毒學雜誌
중화실험화림상병독학잡지
CHINESE JOURNAL OF EXPERIMENTAL AND CLINICAL VIROLOGY
2010年
2期
131-133
,共3页
蔡森%王凯%韩利岩%范玉琛%葛剑%于淑霞%李凤彩%王丽媛%韩婕
蔡森%王凱%韓利巖%範玉琛%葛劍%于淑霞%李鳳綵%王麗媛%韓婕
채삼%왕개%한리암%범옥침%갈검%우숙하%리봉채%왕려원%한첩
肝炎,乙型,慢性%胆红素%丙二醛%黄嘌呤类%氧化还原酶类%抗坏血酸%维生素E%活性氧
肝炎,乙型,慢性%膽紅素%丙二醛%黃嘌呤類%氧化還原酶類%抗壞血痠%維生素E%活性氧
간염,을형,만성%담홍소%병이철%황표령류%양화환원매류%항배혈산%유생소E%활성양
Hepatitis B,chronic%Bilirubin%Malondialdehyde%Xanthines%Oxidoreductases%Ascorbic acid%Vitamin E%Reactive oxygen species
目的 探讨慢性乙型肝炎(CHB)高胆红素血症患者氧化损伤的情况.方法 75例血清总胆红素(TBIL)高于正常上限值(ULN)的CHB患者,按TBIL为ULN的倍数分为A、B、C、D、E五组.测定患者血清丙二醛(MDA)、黄嘌呤氧化酶(XOD)、维生素C(V_C)、维生素E(V_E)浓度,并做出统计分析.11例健康志愿者为正常对照组,16例乙肝表面抗原(HBsAg)携带者为携带者组.结果 各患者组与正常对照组比较:MDA、XOD浓度升高,差异有统计学意义(P<0.05),V_C、V_E浓度降低,差异有统计学意义(P<0.05);携带者组与正常对照组比较:XOD浓度升高,差异有统计学意义(P<0.05),MDA、V_C、V_E浓度差异无统计学意义(P>0.05).在CHB高胆红素血症患者中,MDA、XOD浓度与TBIL水平呈正相关(r=0.670,P<0.01;r=0.737,P<0.01);V_C、V_E浓度与TBIL水平呈负相关(r=-0.463,P<0.01;r=-0.247,P<0.05).各患者组间的比较:除A、B组间外,其余各组间MDA浓度差异有统计学意义(P<0.05);A、B、C组与D、E组间XOD浓度差异有统计学意义(P<0.05);A组与D、E组,B、C、D组与E组间V_C浓度差异有统计学意义(P<0.05);A、B组与E组间V_E浓度差异有统计学意义(P<0.05).结论 CHB高胆红素血症患者体内存在氧化-抗氧化功能障碍,血清TBIL水平升高时氧化损伤程度加重.HBsAg携带者体内氧化损伤程度不高.抗氧化损伤可能有助于CHB高胆红素血症患者的治疗.
目的 探討慢性乙型肝炎(CHB)高膽紅素血癥患者氧化損傷的情況.方法 75例血清總膽紅素(TBIL)高于正常上限值(ULN)的CHB患者,按TBIL為ULN的倍數分為A、B、C、D、E五組.測定患者血清丙二醛(MDA)、黃嘌呤氧化酶(XOD)、維生素C(V_C)、維生素E(V_E)濃度,併做齣統計分析.11例健康誌願者為正常對照組,16例乙肝錶麵抗原(HBsAg)攜帶者為攜帶者組.結果 各患者組與正常對照組比較:MDA、XOD濃度升高,差異有統計學意義(P<0.05),V_C、V_E濃度降低,差異有統計學意義(P<0.05);攜帶者組與正常對照組比較:XOD濃度升高,差異有統計學意義(P<0.05),MDA、V_C、V_E濃度差異無統計學意義(P>0.05).在CHB高膽紅素血癥患者中,MDA、XOD濃度與TBIL水平呈正相關(r=0.670,P<0.01;r=0.737,P<0.01);V_C、V_E濃度與TBIL水平呈負相關(r=-0.463,P<0.01;r=-0.247,P<0.05).各患者組間的比較:除A、B組間外,其餘各組間MDA濃度差異有統計學意義(P<0.05);A、B、C組與D、E組間XOD濃度差異有統計學意義(P<0.05);A組與D、E組,B、C、D組與E組間V_C濃度差異有統計學意義(P<0.05);A、B組與E組間V_E濃度差異有統計學意義(P<0.05).結論 CHB高膽紅素血癥患者體內存在氧化-抗氧化功能障礙,血清TBIL水平升高時氧化損傷程度加重.HBsAg攜帶者體內氧化損傷程度不高.抗氧化損傷可能有助于CHB高膽紅素血癥患者的治療.
목적 탐토만성을형간염(CHB)고담홍소혈증환자양화손상적정황.방법 75례혈청총담홍소(TBIL)고우정상상한치(ULN)적CHB환자,안TBIL위ULN적배수분위A、B、C、D、E오조.측정환자혈청병이철(MDA)、황표령양화매(XOD)、유생소C(V_C)、유생소E(V_E)농도,병주출통계분석.11례건강지원자위정상대조조,16례을간표면항원(HBsAg)휴대자위휴대자조.결과 각환자조여정상대조조비교:MDA、XOD농도승고,차이유통계학의의(P<0.05),V_C、V_E농도강저,차이유통계학의의(P<0.05);휴대자조여정상대조조비교:XOD농도승고,차이유통계학의의(P<0.05),MDA、V_C、V_E농도차이무통계학의의(P>0.05).재CHB고담홍소혈증환자중,MDA、XOD농도여TBIL수평정정상관(r=0.670,P<0.01;r=0.737,P<0.01);V_C、V_E농도여TBIL수평정부상관(r=-0.463,P<0.01;r=-0.247,P<0.05).각환자조간적비교:제A、B조간외,기여각조간MDA농도차이유통계학의의(P<0.05);A、B、C조여D、E조간XOD농도차이유통계학의의(P<0.05);A조여D、E조,B、C、D조여E조간V_C농도차이유통계학의의(P<0.05);A、B조여E조간V_E농도차이유통계학의의(P<0.05).결론 CHB고담홍소혈증환자체내존재양화-항양화공능장애,혈청TBIL수평승고시양화손상정도가중.HBsAg휴대자체내양화손상정도불고.항양화손상가능유조우CHB고담홍소혈증환자적치료.
Objective To investigate oxidative stress in chronic hepatitis B(CHB) patients with elevated serum total bilirubin(TBIL).Methods 75 CHB patients with elevated serum TBIL were enrolled in the present study.A,B,C,D and E group were defined.Serum Malondialdehyde (MDA),Xanthine Oxidase(XOD),VitaminC (V_C) and VitaminE (V_E) were determined.The control group contained 11 healthy donors and the carrier group contained 16 Hepatitis B surface antigen (HBsAg) carriers.Results The concentrations of MDA and XOD were significantly higher in each group of patients than in the control (P<0.05),while V_C and V_E were significantly lower (P<0.05).The concentration of XOD was significantly higher in the carrier group than in the control (P<0.05),while MDA,V_C and V_E were not significantly different (P>0.05).The concentrations of MDA and XOD were significandy positively correlated with TBIL (r=0.670,P<0.01;r=0.737,P<0.01,respectively) in the patients,while V_C and V_E were significantly negatively correlated with TBIL (r=-0.463,P<0.01;r=-0.247,P<0.05,respectively).The concentration of MDA was significantly different among all the groups in the patients except the comparison between group A and group B.The concentration of XOD was significantly different between group A,B,C and group D,E (P<0.05).The concentration of V_C was significantly different between group A and group D,E and between group B,C,D and group E (P<0.05).The concentration of V_E was significantly different between group A,B and group E (P<0.05).Conclusion There was a disturbance between oxidative stress and anti-oxidative ability in CHB patients with elevated serum TBIL.Oxidative stress became more serious along with the increasing of serum TBIL.In HBsAg carriers,oxidative stress level was low.The results suggest antioxidant treatment for CHB patients with elevated serum TBIL may help to improve the effect of therapy.