CAJ | 학술논문

目的比较奈达铂联合5-氟尿嘧啶(5-Fu)与顺铂联合5-Fu诱导化疗治疗局部中晚期鼻咽癌的疗效和耐受性.方法 100例经病理组织学确诊的Ⅲ、Ⅳa期鼻咽癌患者随机分为奈达铂联合5-Fu组(NF组)和顺铂联合5-Fu组(PF组),每组50例.NF组:奈达铂30 mg/m2,静脉滴注,第1～3天;5-Fu 500 mg/m2,静脉滴注,第1～5天,每3周重复,连续应用2个疗程.PF组:顺铂30 mg/m2,静脉滴注,第1～3天;5-Fu 500 mg/m2,静脉滴注,第1～5天,每3周重复,连续应用2个疗程.采用x2检验比较两组患者的疗效和急性不良反应.结果 50例患者均可进行疗效评价,两组患者的临床资料比较无明显差别.NF组和PF组患者肿瘤全消各3例.NF组的有效率为86.0%,PF组为84.0%,两组差异无统计学意义(x2=0.078,P=0.779).PF组患者恶心、呕吐的发生率(88.0%)明显高于NF组(56.0%,x2=23.268,P=0.000);两组患者外周血白细胞数、血小板数、谷丙转氨酶、尿素氮和肌酐异常的发生率比较,差异无统计学意义(P>0.05).结论奈达铂联合5-Fu是治疗局部中晚期鼻咽癌的有效方案,有效率与PF方案相似.在减少恶心、呕吐方面,奈达铂联合5-Fu有明显的优势.
목적 비교내체박연합5-불뇨밀정(5-Fu)여순박연합5-Fu유도화료치료국부중만기비인암적료효화내수성.방법 100례경병리조직학학진적Ⅲ、Ⅳa기비인암환자수궤분위내체박연합5-Fu조(NF조)화순박연합5-Fu조(PF조),매조50례.NF조:내체박30 mg/m2,정맥적주,제1～3천;5-Fu 500 mg/m2,정맥적주,제1～5천,매3주중복,련속응용2개료정.PF조:순박30 mg/m2,정맥적주,제1～3천;5-Fu 500 mg/m2,정맥적주,제1～5천,매3주중복,련속응용2개료정.채용x2검험비교량조환자적료효화급성불량반응.결과 50례환자균가진행료효평개,량조환자적림상자료비교무명현차별.NF조화PF조환자종류전소각3례.NF조적유효솔위86.0%,PF조위84.0%,량조차이무통계학의의(x2=0.078,P=0.779).PF조환자악심、구토적발생솔(88.0%)명현고우NF조(56.0%,x2=23.268,P=0.000);량조환자외주혈백세포수、혈소판수、곡병전안매、뇨소담화기항이상적발생솔비교,차이무통계학의의(P>0.05).결론 내체박연합5-Fu시치료국부중만기비인암적유효방안,유효솔여PF방안상사.재감소악심、구토방면,내체박연합5-Fu유명현적우세.
Objective To compare the efficacy and side effects of nedaplatin plus 5-fluorouracil (5-Fu) and cisplatin plus 5-Fu for treatment of stage Ⅲ-Ⅳa nasopharyngeal carcinoma (NPC).Methods A total of 100 patients with NPC proved by histopathology were divided into nedaplatin plus 5-Fu group ( NF group) and cisplatin plus 5-Fu group (PF group), 50 cases in each group.NF group:nedaplatin 30 mg/m2,d1-d3, 5-Fu 500 mg/m2 d1-d5, repeated every 3 weeks for2 cycles.PF group:cisplatin 30 mg/m2 d1-d3, 5-Fu 500 mg/m2 d1-d5, repeated every 3 weeks for 2 cycles.x2 test was used to compare the efficacy and sideeffects of the two groups.Results All the 100 cases were evaluable and their clinical data in the two groups were comparable.Six patients with complete response were observed, 3 cases in NF group and 3 in PF group.The overall response rates were 86.0% in NF group and 84.0% in PF group, with no significant difference (x2 = 0.078, P = 0.779 ).The rates of leukocytopenia, thrombocytopenia, impairment of hepatic and renal function were similar whereas more patients in the PF group than in the NF group suffered from nausea and vomiting ( 88.0% vs.56.0%, P = 0.000).Conclusions Nedaplatin plus 5-Fu is an effective treatment regimen for NPC.When compared with PF regimen, the response rate is similar.However, NF regimen shows a significant superiority in reducing nausea and vomiting.