CAJ | 학술논문

目的:观察长期应用来氟米特治疗类风湿关节炎(类风关)的疗效和不良反应.方法:21例类风关病人[男性2例,女性19例;年龄(45±s9)a;病程(59 ±48)mo],首先应用来氟米特20 mg,po,qd进行为期0.5 a的双盲、单盲试验,以后又继续按原剂量用药并随访,其中有9例服药6 mo至1 a后改用10 mg,po, qd.结果:21例随访1.5 a(包括双盲、单盲试验的6 mo,下同),临床缓解1例,显效20例;19例随访2 a, 临床缓解7例,显效12例;17例随访2.5 a,临床缓解10例,显效7例;12例随访3 a,临床缓解9例,显效3例.X线双手正位片3 a随访中无变化6例.先后发生不良反应共计为19 %(4/ 2 1例).结论:来氟米特长期治疗类风关疗效好、不良反应少.
목적:관찰장기응용래불미특치료류풍습관절염(류풍관)적료효화불량반응.방법:21례류풍관병인[남성2례,녀성19례;년령(45±s9)a;병정(59 ±48)mo],수선응용래불미특20 mg,po,qd진행위기0.5 a적쌍맹、단맹시험,이후우계속안원제량용약병수방,기중유9례복약6 mo지1 a후개용10 mg,po, qd.결과:21례수방1.5 a(포괄쌍맹、단맹시험적6 mo,하동),림상완해1례,현효20례;19례수방2 a, 림상완해7례,현효12례;17례수방2.5 a,림상완해10례,현효7례;12례수방3 a,림상완해9례,현효3례.X선쌍수정위편3 a수방중무변화6례.선후발생불량반응공계위19 %(4/ 2 1례).결론:래불미특장기치료류풍관료효호、불량반응소.
AIM: To investigate the efficacy and safety of leflunomide (Lef) in long-term treatm ent of rheumatoid arthritis (RA).　METHODS: Twenty-one patients ［M 2,F 19; age (45±s 9)a］ with RA were s elected. Disease duration was (59±48) mo. All patients enrolled in double-blin d or single-blind trials with Lef 20 mg, po, qd for 6 mo at first. Doses of leflunomide in nine patients were reduced down to 10 mg, qd and all the others c ontinued the treatment with Lef at 20 mg, qd. 　RESULTS: All twenty-one patient s we re followed up for 1.5 a. The results showed that twenty patients had remarkable improvement and one patient had clinical remission. Ni neteen patients had been followed up for more than 2 a and twelve patients had r emarkable improvement while seven patients had clinical remission. Twelve pati ents had been followed up for 3 a and three of them had remarkable improvement while nine patients had clinical remission. Total rate of adverse reactions was 19 %( 4/21). 　CONCLUSION: This study shows that long-term treatment of RA with Lef is effec tive and safe.