CAJ | 학술논문

目的:观察鱼腥草素对大鼠动脉硬化及其炎症相关细胞因子的影响.方法:将大鼠随机分为正常纽、模型组、鱼腥草素低剂量组、鱼腥草素高剂量组和布洛芬组.模型组及各给药组采用一次性腹腔注射维生素D3 60万单位/kg,同时每天灌服10 mL/kg脂肪乳的方法制备大鼠动脉硬化模型.鱼腥草素低剂量组和高剂量组分别每天灌服鱼腥草素39 mg/(kg·d)和78 mg/(kg·d),布洛芬组每天灌服布洛芬混悬液144 mg/(kg·d),正常组和模型组每天灌服等量蒸馏水.给药70 d后处死大鼠,对血脂、TNF-α、IL-1β、IL-6、IL-10及NF-κB进行测定,并观察动脉的病变情况.结果:鱼腥草素可明显降低模型大鼠胆固醇和低密度脂蛋白的水平,提高高密度脂蛋白与低密度脂蛋白的比值,降低炎症因子TNF-α、IL-1β、IL-6的浓度,提高抗炎因子IL-10的浓度,抑制动脉NF-κB过量表达,抑制模型大鼠动脉壁中膜的增厚.结论:鱼腥草素可通过抗炎和降血脂而发挥一定的抗动脉硬化的作用.
목적:관찰어성초소대대서동맥경화급기염증상관세포인자적영향.방법:장대서수궤분위정상뉴、모형조、어성초소저제량조、어성초소고제량조화포락분조.모형조급각급약조채용일차성복강주사유생소D3 60만단위/kg,동시매천관복10 mL/kg지방유적방법제비대서동맥경화모형.어성초소저제량조화고제량조분별매천관복어성초소39 mg/(kg·d)화78 mg/(kg·d),포락분조매천관복포락분혼현액144 mg/(kg·d),정상조화모형조매천관복등량증류수.급약70 d후처사대서,대혈지、TNF-α、IL-1β、IL-6、IL-10급NF-κB진행측정,병관찰동맥적병변정황.결과:어성초소가명현강저모형대서담고순화저밀도지단백적수평,제고고밀도지단백여저밀도지단백적비치,강저염증인자TNF-α、IL-1β、IL-6적농도,제고항염인자IL-10적농도,억제동맥NF-κB과량표체,억제모형대서동맥벽중막적증후.결론:어성초소가통과항염화강혈지이발휘일정적항동맥경화적작용.
AIM: To study the effect of decanoyl acetaldehyde against atherosclerosis and the relative mechanisms in rats.METHODS: Rats were randomly assigned into 5 groups,That were the control,model,low and high dose of decanoyl acetaldehyde and ibuprofen groups.The model rats were intraperitoneally injected with 600 000 IU/kg vitamine Ds and intragastricly administrated with high-fat emulsion 10 mL/( kg·d) for 70 days.At the same time,the model rats treated with drugs were orally given 39 mg/( kg·d),78 mg/( kg·d) decanoyl acetaldehyde and 144 mg/( kg·d) ibuprofen suspension respectively.After 70 days,the rats were euthakilled,and the serum level of TC,LDL-C,HDL-C/LDL-C ,TNF-α,IL-1β,IL-6,IL-10,the expression of NF-κB in rat aorta and the pathological change in aorta were measured.RESULTS: Decanoyl acetaldehyde could lower the serum level of TC,LDL-C,TNF-α,IL-1β and IL-6.It increased the level of IL-10 and the ratio of HDL-C/LDL-C,inhibited the expression of NF-κB and reduced the thickness of the artery wall.CONCLUSION : Decanoyl acetaldehyde has an effect on anti-atherosclerosis.The mechanism may be related with inhibiting inflammation and lowering serum lipid.