CAJ | 학술논문

超临界溶液浸渍法(supercritical solution impregnation,SSI)是一种将小分子物质负载到聚合物中的过程技术,主要是利用超临界流体的高扩散系数、低黏度及其对聚合物的溶胀作用,使小分子物质通过分子扩散作用迅速进入溶胀的聚合物并包裹于其中.近年来该技术已用于制备缓释药物/聚合物复合微球、薄膜和纤维等.该法的主要优点在于载体结构灵活,拓展了超临界技术在控释药物制备中的应用.本文主要介绍了SSI法的原理、流程及其在缓释药物制备中的应用,并展望了SSI法的发展趋势.
초림계용액침지법(supercritical solution impregnation,SSI)시일충장소분자물질부재도취합물중적과정기술,주요시이용초림계류체적고확산계수、저점도급기대취합물적용창작용,사소분자물질통과분자확산작용신속진입용창적취합물병포과우기중.근년래해기술이용우제비완석약물/취합물복합미구、박막화섬유등.해법적주요우점재우재체결구령활,탁전료초림계기술재공석약물제비중적응용.본문주요개소료SSI법적원리、류정급기재완석약물제비중적응용,병전망료SSI법적발전추세.
Supercritical solution impregnation (SSI) is a novel technology in which low molecular weight substances are loaded into the polymer matrix and has been recently used in the preparation of control-released drug/polymer complex microparticles, films and fibers.This process utilizes mainly the high diffusion coefficient and low viscosity of supercritical fluid and the swelling of polymer in the supercritical fluid.The advantages of SSI are the easy changes of the polymer matrix structure, which makes possible the application of SC-CO_2 in control-released drug delivery system.In this review, the principle, apparatus and application of SSI in the preparation of control-released drugs are introduced, and the development of this technology is also presented.