国际肿瘤学杂志
國際腫瘤學雜誌
국제종류학잡지
JOURNAL OF INTERNATIONAL ONCOLOGY
2009年
7期
550-553
,共4页
赵杰%夏金堂%李雯%张珑涓%王花%伍兆锋%滕元%徐晨
趙傑%夏金堂%李雯%張瓏涓%王花%伍兆鋒%滕元%徐晨
조걸%하금당%리문%장롱연%왕화%오조봉%등원%서신
胰腺肿瘤%巨噬细胞游走抑制因子%细胞周期蛋白D1%肿瘤转移
胰腺腫瘤%巨噬細胞遊走抑製因子%細胞週期蛋白D1%腫瘤轉移
이선종류%거서세포유주억제인자%세포주기단백D1%종류전이
Pancreatic neoplasms%Macrophage migration-inhibitor factor%Cyclin D1%Neoplasm me-tastasis
目的 探讨巨噬细胞移动抑制因子(MIF)和细胞周期蛋白D1(cyclin D1)的表达及其与胰腺癌临床病理特征的关系及意义.方法 免疫组化方法 检测胰腺肿瘤和正常胰腺组织中MIF和Cyc-lin D1的表达,分析其表达与胰腺肿瘤临床病理特征的关系.结果 89例胰腺癌组织中MIF和Cy-clinD1阳性表达率分别为88.8%和50.6%.临床分期Ⅰ、Ⅱ、Ⅲ、Ⅳ期病例中MIF表达率分别为69.2%、94.7%、96.4%、100%,Ⅰ期与各期之间表达率的差异均有统计学意义(P<0.05);CyclinD1表达率分别为30.8%、47.4%、33.3%、68.8%.Ⅰ期表达率与Ⅲ、Ⅳ期之间的差异均有统计学意义(P<0.05),与Ⅱ期之间差异无统计学意义.MIF表达与CyclinD1表达呈正相关(P<0.05).伴淋巴结转移病例中MIF和CyclinD1阳性表达率(97.5%和62.5%)均高于无淋巴结转移的胰腺肿瘤组织(81.6%和40.8%),差异均有统计学意义(P<0.05).发生肝转移的胰腺肿瘤组织中MIF表达率高于无肝转移组织(100%:85.9%,P>0.05),CyclinD1表达率显著高于无肝转移组织(66.7%:46.5%,P<0.05).高、中、低分化组胰腺肿瘤组织中MIF和CyclinD1阳性表达率分别为61.9%、73.8%、96.2%和28.6%、45.2%、76.9%,3组之间差异均有统计学意义(P<0.05).结论 MIF和CyclinD1过表达与胰腺肿瘤的临床分期、淋巴结和肝转移及组织分化密切相关.
目的 探討巨噬細胞移動抑製因子(MIF)和細胞週期蛋白D1(cyclin D1)的錶達及其與胰腺癌臨床病理特徵的關繫及意義.方法 免疫組化方法 檢測胰腺腫瘤和正常胰腺組織中MIF和Cyc-lin D1的錶達,分析其錶達與胰腺腫瘤臨床病理特徵的關繫.結果 89例胰腺癌組織中MIF和Cy-clinD1暘性錶達率分彆為88.8%和50.6%.臨床分期Ⅰ、Ⅱ、Ⅲ、Ⅳ期病例中MIF錶達率分彆為69.2%、94.7%、96.4%、100%,Ⅰ期與各期之間錶達率的差異均有統計學意義(P<0.05);CyclinD1錶達率分彆為30.8%、47.4%、33.3%、68.8%.Ⅰ期錶達率與Ⅲ、Ⅳ期之間的差異均有統計學意義(P<0.05),與Ⅱ期之間差異無統計學意義.MIF錶達與CyclinD1錶達呈正相關(P<0.05).伴淋巴結轉移病例中MIF和CyclinD1暘性錶達率(97.5%和62.5%)均高于無淋巴結轉移的胰腺腫瘤組織(81.6%和40.8%),差異均有統計學意義(P<0.05).髮生肝轉移的胰腺腫瘤組織中MIF錶達率高于無肝轉移組織(100%:85.9%,P>0.05),CyclinD1錶達率顯著高于無肝轉移組織(66.7%:46.5%,P<0.05).高、中、低分化組胰腺腫瘤組織中MIF和CyclinD1暘性錶達率分彆為61.9%、73.8%、96.2%和28.6%、45.2%、76.9%,3組之間差異均有統計學意義(P<0.05).結論 MIF和CyclinD1過錶達與胰腺腫瘤的臨床分期、淋巴結和肝轉移及組織分化密切相關.
목적 탐토거서세포이동억제인자(MIF)화세포주기단백D1(cyclin D1)적표체급기여이선암림상병리특정적관계급의의.방법 면역조화방법 검측이선종류화정상이선조직중MIF화Cyc-lin D1적표체,분석기표체여이선종류림상병리특정적관계.결과 89례이선암조직중MIF화Cy-clinD1양성표체솔분별위88.8%화50.6%.림상분기Ⅰ、Ⅱ、Ⅲ、Ⅳ기병례중MIF표체솔분별위69.2%、94.7%、96.4%、100%,Ⅰ기여각기지간표체솔적차이균유통계학의의(P<0.05);CyclinD1표체솔분별위30.8%、47.4%、33.3%、68.8%.Ⅰ기표체솔여Ⅲ、Ⅳ기지간적차이균유통계학의의(P<0.05),여Ⅱ기지간차이무통계학의의.MIF표체여CyclinD1표체정정상관(P<0.05).반림파결전이병례중MIF화CyclinD1양성표체솔(97.5%화62.5%)균고우무림파결전이적이선종류조직(81.6%화40.8%),차이균유통계학의의(P<0.05).발생간전이적이선종류조직중MIF표체솔고우무간전이조직(100%:85.9%,P>0.05),CyclinD1표체솔현저고우무간전이조직(66.7%:46.5%,P<0.05).고、중、저분화조이선종류조직중MIF화CyclinD1양성표체솔분별위61.9%、73.8%、96.2%화28.6%、45.2%、76.9%,3조지간차이균유통계학의의(P<0.05).결론 MIF화CyclinD1과표체여이선종류적림상분기、림파결화간전이급조직분화밀절상관.
Objective To evaluate the expression of macrophage migration inhibitor factor (MiF) and cyclinD1 in pancreatic carcinoma and their relationships with clinical pathology characteristics. Methods The expression of MIF and eyclinD1 in 89 carcinoma and 5 normal pancreatic tissues was detected with immunohis-tochemistry methods, and the relationships among MIF and cyclinD1 expression and clinicopathological factors were studied. Results The overexpression of MIF and cyclinD1 was found in 88.8%, and 50. 6% of pancre-atic carcinoma tissues respectively. The overexpression of MIF had a significant correlation with Ⅰ,Ⅱ,Ⅲ,Ⅳ tumor stage (69. 2%, 94. 7%, 96. 4%, 100%, P <0.05), while the positive expression rate of cyclinD1 only had a significant correlation with tumor stages Ⅲ,Ⅳ (33. 3%, 68. 8%, P <0. 05). Both of the two proteins had a correlative tendency with pathological grade and lymph node metastasis. The different expression of MIF between pancreatic carcinoma with and without liver metastasis had no statistical significance, (100% ,85.9%, P >0. 05)while there was a statistically significant difference about cyclinD1 (66. 7% ,46. 5% ,P <0. 05). A significant positive correlation was also found between MIF and cyclinD1 (P < 0. 05). Conclusion The ex-pression of MIF and CyclinD1 was higher in pancreatic cancer tissues than in normal tissue, and they may be associated with the malignant stage, tumor differentiation, local lymph node and liver metastasis of this tumor.