CAJ | 학술논문

目的探讨瑞格列奈联合二甲双胍在2型糖尿病治疗中的应用价值.方法选择2型糖尿病患者92例,随机分为观察组和对照组.两组患者均给予瑞格列奈治疗,观察组则在此基础上加用二甲双胍,并对两组患者的糖代谢和血脂以及体质量变化等临床疗效进行比较分析.结果与对照组相比,观察组治愈率和总有效率分别为58.7％和97.8％,无效率为2.2％,差异均有统计学意义(x2=2.64,3.59,3.59,P＜0.05)；观察组空腹血糖和餐后2h血糖以及糖化血红蛋白等糖代谢指标均显著降低(P＜0.05)；观察组的三酰甘油和胆固醇等血脂指标以及体质量指数均显著降低(P＜0.05).结论瑞格列奈联合二甲双胍对于提高2型糖尿病患者的临床疗效具有十分重要的意义.
목적 탐토서격렬내연합이갑쌍고재2형당뇨병치료중적응용개치.방법 선택2형당뇨병환자92례,수궤분위관찰조화대조조.량조환자균급여서격렬내치료,관찰조칙재차기출상가용이갑쌍고,병대량조환자적당대사화혈지이급체질량변화등림상료효진행비교분석.결과 여대조조상비,관찰조치유솔화총유효솔분별위58.7％화97.8％,무효솔위2.2％,차이균유통계학의의(x2=2.64,3.59,3.59,P＜0.05)；관찰조공복혈당화찬후2h혈당이급당화혈홍단백등당대사지표균현저강저(P＜0.05)；관찰조적삼선감유화담고순등혈지지표이급체질량지수균현저강저(P＜0.05).결론 서격렬내연합이갑쌍고대우제고2형당뇨병환자적림상료효구유십분중요적의의.
Objective To explore the application value of repaglinide combined with metformin in type 2 diabetes therapy.Methóds 92 patients with type 2 diabetes were randomly divided into study group and control group.Two groups of patients were given repaglinide treatment,patients in study group given metformin treatment.The blood lipid,glucose metabolism,body weight change and clinical outcomes were compared belween the groups.Results Compared with the control group,study group the cure rate and total effective rate was significantly increased,as high as 58.7％ and 97.8％,the ineffective rate was significantly decreased,only 2.2％,there were significant differences ( x2 =2.64,3.59,3.59,P ＜ 0.05 ).The fasting and 2h postprandial blood glucose and glycated hemoglobin and other indicators of glucose metabolism in the study group were significantly decreased,there were also significant differences(P ＜ 0.05 ).The triglycerides and cholesterol and other lipid levels and body mass index in the study group were significantly decreased,there were significant differences ( P ＜ 0.05 ).Conclusion Repaglinide combined with metformin in type 2 diabetes treatment was remarkable for type 2 diabetes to further improve the clinical efficacy.