CAJ | 학술논문

目的探讨急性冠脉综合征(ACS)患者冠状动脉病变程度与血浆抵抗素(Resistin)水平的关系.方法研究共入选400例,包括对照组90例,冠心病(CHD)组310例,其中ACS亚组217例,稳定型心绞痛(SAP)亚组93例;对各组行选择性冠状动脉造影检查及外周血浆Resistin浓度检测,分析各组冠脉病变程度与血浆Resistin水平之间的关系;CHD组中85例患者接受64层螺旋CT冠状动脉成像检查评价冠状动脉粥样斑块类型并行亚组分析.结果 CHD组Resistin水平[(889.1±248.2)pg/ml]明显高于对照组[(261.6±111.9)pg/ml](P＜0.05);CHD组内,ACS亚组Resistin水平[(1260.0±368.0)pg/ml]明显高于SAP亚组[(518.3±128.4)pg/ml](P＜0.05),软斑块亚组血清抵抗素水平[(1097.83±259.69)pg/ml]、纤维斑块亚组[(981.46±107.73)pg/ml]较钙化斑块亚组[(487.92±98.52)pg/ml]血浆Resistin水平明显升高,差异有统计学意义(P＜0.05);逐步回归分析表明血浆Resistin水平与冠脉病变Gensini评分有显著相关性.结论 CHD患者(尤其是ACS患者)血浆Resistin水平明显增高,并随冠脉病变严重程度的增加而升高,提示血浆Resistin可能促进易损斑块的形成.血浆Resistin水平结合64层螺旋CT检测可初步判断冠状动脉粥样斑块的稳定性.
목적 탐토급성관맥종합정(ACS)환자관상동맥병변정도여혈장저항소(Resistin)수평적관계.방법 연구공입선400례,포괄대조조90례,관심병(CHD)조310례,기중ACS아조217례,은정형심교통(SAP)아조93례;대각조행선택성관상동맥조영검사급외주혈장Resistin농도검측,분석각조관맥병변정도여혈장Resistin수평지간적관계;CHD조중85례환자접수64층라선CT관상동맥성상검사평개관상동맥죽양반괴류형병행아조분석.결과 CHD조Resistin수평[(889.1±248.2)pg/ml]명현고우대조조[(261.6±111.9)pg/ml](P＜0.05);CHD조내,ACS아조Resistin수평[(1260.0±368.0)pg/ml]명현고우SAP아조[(518.3±128.4)pg/ml](P＜0.05),연반괴아조혈청저항소수평[(1097.83±259.69)pg/ml]、섬유반괴아조[(981.46±107.73)pg/ml]교개화반괴아조[(487.92±98.52)pg/ml]혈장Resistin수평명현승고,차이유통계학의의(P＜0.05);축보회귀분석표명혈장Resistin수평여관맥병변Gensini평분유현저상관성.결론 CHD환자(우기시ACS환자)혈장Resistin수평명현증고,병수관맥병변엄중정도적증가이승고,제시혈장Resistin가능촉진역손반괴적형성.혈장Resistin수평결합64층라선CT검측가초보판단관상동맥죽양반괴적은정성.
Objective To explore the association between plasma resistin levels and acute coronary syndrome. Methods Four hundred patients were divided into coronary heart disease (CHD) group（310）and control group（90）according to the coronary Angiography (CAG). And CHD group was divided into ACS subgroup（n＝217）and SAP subgroup（n＝93）according to the clinical information. 85 cases in CHD group were underwent 64-slice spiral computed tomography coronary artery imaging. The severity and extent of coronary lesions were analyzed by CAG and graded by means of Gensini coronary score system. Resistin level in plasma of all patients was determined by enzyme linked immunosorbent assay. Results Resistin levels in CHD group［(889.1±248.2)pg/ml］ were significant higher compared with the control group［(261.6±111.9)pg/ml］ (P＜0.05), and resistin levels in ACS subgroup［(1260.0±368.0)pg/ml］ were much higher than that in SAP subgroup［(518.3±128.4)pg/ml］ (P＜0.05). Conclusions The resistin levels of patients with acute coronary syndrome increased significantly and might be associated with the vulnerable plaque. Resistin levels and 64 slice spiral computed tomography coronary artery imaging can be used to detect the vulnerable plaque in CHD patients.