CAJ | 학술논문

目的探讨术后放疗对胰腺癌患者生存率的影响.方法 44例胰腺癌患者分为手术组(根治性外科切除)和手术+放疗组(根治性外科切除后接受外放疗),比较两组患者的治疗效果.结果手术组平均生存期为453 d,中位生存期为379 d.手术+放疗组平均生存期789 d,中位生存期为665 d.手术组和手术+放疗组的1、3、5年生存率分别为46.3%、8.3%、4.2%和65.2%、20.2%、14.1%,手术+放疗组优于手术组(P=0.017).手术+放疗组局部复发率及区域淋巴结转移率低于手术组(P<0.05),且并发症发生率并不高于手术组(P>0.05).结论胰腺癌根治术后结合放疗有助于改善患者生存期.
목적 탐토술후방료대이선암환자생존솔적영향.방법 44례이선암환자분위수술조(근치성외과절제)화수술+방료조(근치성외과절제후접수외방료),비교량조환자적치료효과.결과 수술조평균생존기위453 d,중위생존기위379 d.수술+방료조평균생존기789 d,중위생존기위665 d.수술조화수술+방료조적1、3、5년생존솔분별위46.3%、8.3%、4.2%화65.2%、20.2%、14.1%,수술+방료조우우수술조(P=0.017).수술+방료조국부복발솔급구역림파결전이솔저우수술조(P<0.05),차병발증발생솔병불고우수술조(P>0.05).결론 이선암근치술후결합방료유조우개선환자생존기.
Objective To retrospectively investigate the difference in survival of pancreatic adenocarcinoma patients treated by radical surgery with or without adjuvant radiation therapy. Methods Forty-four patients with pancreatic cancer underwent surgical resection with a curative intent, and were divided into two groups: surgery alone (n=24) or surgery combined with postoperative external beam radiotherapy (EBRT) (n=20). Survival as an endpoint was analyzed between the two groups. Results All 44 patients completed their scheduled treatment. The median survival time of the patients treated with radical resection alone was 379 days versus 665 days for those treated with combined therapy. The 1-,3-,5-year survival rates of the patients treated with radical resection alone were 46.3%, 8.3%, 4.2% versus 65.2%, 20.2%, 14.1% for the patients treated with combined therapy, respectively, with a significant difference between the two groups (P=0.017). The failures in local-regional relapse were significantly lower in the postoperative EBRT group than that in the surgery alone group (P<0.05), while the additional postoperative radiation therapy did not increase the complication rate (P>0.05). Conclusion Postoperative external beam radiation therapy can improve the survival in patients with pancreatic adenocarcinoma.