CAJ | 학술논문

目的比较几种不平衡氨基酸营养支持对肿瘤生长的影响。方法荷Walker-256癌肉瘤SD大鼠，空肠喂饲肠外营养制剂10天，据所喂饲制剂中氨基酸组成的不同，分为：A组（平衡氨基酸组）、B组（增量精氨酸不平衡氨基酸组）、C组（去蛋氨酸不平衡氨基酸组）、D组（去缬氨酸不平衡氨基酸组）、E组（增量精氨酸、去蛋氨酸、去缬氨酸不平衡氨基酸组）。肿瘤体积增长速度、肿瘤重量、肿瘤重量/尸重，肿瘤组织PCNA指数，肿瘤细胞周期各时相百分比以及DNA倍性作为观察肿瘤生长速度的指标。结果上述各指标值显示：B、C、D组与A组相比，除DNA倍性外，其余各指标值均降低(P<0.01)，但B、C、D组间比较无显著性差异(P>0.05）。E组与B、C、D组相比较，所有指标值均显著降低(P<0.05)。结论平衡氨基酸促进肿瘤生长；增量精氨酸、去蛋氨酸、去缬氨酸三种不平衡氨基酸对肿瘤生长有同等抑制作用；增量精氨酸、去蛋氨酸、去缬氨酸复合不平衡氨基酸对肿瘤生长抑制作用更显著。
목적비교궤충불평형안기산영양지지대종류생장적영향。방법하Walker-256암육류SD대서，공장위사장외영양제제10천，거소위사제제중안기산조성적불동，분위：A조（평형안기산조）、B조（증량정안산불평형안기산조）、C조（거단안산불평형안기산조）、D조（거힐안산불평형안기산조）、E조（증량정안산、거단안산、거힐안산불평형안기산조）。종류체적증장속도、종류중량、종류중량/시중，종류조직PCNA지수，종류세포주기각시상백분비이급DNA배성작위관찰종류생장속도적지표。결과상술각지표치현시：B、C、D조여A조상비，제DNA배성외，기여각지표치균강저(P<0.01)，단B、C、D조간비교무현저성차이(P>0.05）。E조여B、C、D조상비교，소유지표치균현저강저(P<0.05)。결론평형안기산촉진종류생장；증량정안산、거단안산、거힐안산삼충불평형안기산대종류생장유동등억제작용；증량정안산、거단안산、거힐안산복합불평형안기산대종류생장억제작용경현저。
Objective To study effects of imbalance amino acids nutritionsupport on tumor growth in tumor-bearing rats. Methods Parenteral nutritional solution had been fed for 10 days by jejumostomy in rats bearing Walker-256 carcinosarcoma. The tumor-bearing rats were divided into five different groups according to formulas of amino acids in parenteral nutritional solution respectively: group A (balance amino acid), group B (arginine-enriched amino acid), group C (methionine-depleted amino acid), group D (valine-depleted amino acid) and group E (complex amino acids of arginine-enriched、methionine depleted and valine-depleted) . Indices of tumor growth: tumor volume、tumor weight、tumor weight/carcass body weight、the expression of proliferating cell nuclear antigen (PCNA)、DNA ploidy and cell cycle of tumor tissue were investigated. Results The levels of above indice except DNA ploidy were as follows: group B、C and D were significantly lower than group A (P<0.01), but there were no significant difference among group B、C and D (P>0.05). All tumor growth indices of group E were significantly less than those of group B、C and D (P<0.05). Conclusions Balance amino acid stimulates tumor growth;Arginine enriched、methionine-depleted and valine-depleted amino acids inhibit tumor growth; Complex amino acids of arginine-enriched、methionine-depleted and valine-depleted have stronger inhibitory effect on tumor growth.