CAJ | 학술논문

目的：观察顺尔宁治疗儿童哮喘的临床疗效及对血清白细胞4（IL-4）、白细胞介素17（IL-17）及免疫球蛋白E（IgE）水平的影响。方法88例哮喘患者随机分为两组，对照组采用常规治疗，治疗组在此基础上加用顺尔宁片，观察两组临床疗效和治疗前后炎症介质及IgE水平变化情况。结果治疗组有效率明显高于对照组（P＜0.05）；两组治疗后血清IL-4、IL-17及IgE水平较治疗前明显改善（P＜0.05或P＜0.01）；且治疗组下降幅度更为显著（P＜0.05）。结论顺尔宁治疗儿童哮喘疗效确切，其作用机制可能与降低炎性因子及IgE浓度水平有关。
목적：관찰순이저치료인동효천적림상료효급대혈청백세포4（IL-4）、백세포개소17（IL-17）급면역구단백E（IgE）수평적영향。방법88례효천환자수궤분위량조，대조조채용상규치료，치료조재차기출상가용순이저편，관찰량조림상료효화치료전후염증개질급IgE수평변화정황。결과치료조유효솔명현고우대조조（P＜0.05）；량조치료후혈청IL-4、IL-17급IgE수평교치료전명현개선（P＜0.05혹P＜0.01）；차치료조하강폭도경위현저（P＜0.05）。결론순이저치료인동효천료효학절，기작용궤제가능여강저염성인자급IgE농도수평유관。
Objective To investigate the clinical efficacy of singulair in the treatment of asthma in children and its impact on serum leukocyte-4(IL-4), interleukin-17(IL-17) and immunoglobulin E(IgE) levels. Methods Eighty-eight children with asthma were randomly divided into two groups.The control group received conventional therapy and the treatment group received singulair tablets on the basis of the control group. The clinical efficacy and the changes of inflammatory mediators and IgE levels of the two groups after treatment were observed. Results The treatment group had significantly higher effective rate than the control group(P<0.05);The serum IL-4, IL-17 and IgE levels of the two groups after treatment improved significantly compared to those before treatment(P<0.05 or P<0.01);And the treament group decreased more significantly(P < 0.05). Conclusion Singulair shows accurate efficacy in the treatment of asthma in children and its acting mechanism may relate to the reduction of inflammatory factors and IgE levels.