CAJ | 학술논문

WIF-1(Wnt inhibitory factor-1)最早作为人视网膜表达序列标签被人们所认识,后被证明是一种Wnt分子的胞外抑制剂,属于sFRP家族.WIF-1可以直接与Wnt分子结合,抑制Wnt分子与受体细胞膜上的Frizzled受体及辅助受体LRP5/6形成三聚体复合物,从而抑制了信号传导. Wif1 在斑马鱼、爪蟾、小鼠和人的神经系统均有表达,参与爪蟾神经系统A-P轴的分化,影响小鼠视杆细胞的形成. Wif1 在胚胎期小鼠中枢神经系统中表达强烈,提示在胚胎期神经系统发育中, Wif1 可能对Wnt信号通路活性起着时空特异性的调节作用.Wnt信号通路在脊椎动物中枢神经系统发育中发挥着重要的作用,但人们对 Wif1 在神经系统发育中的功能却知之甚少.根据 Wif1 在神经发育中的表达谱信息,可以选取合适的研究时期和部位,研究 Wif1 在神经发育中的功能.
WIF-1(Wnt inhibitory factor-1)최조작위인시망막표체서렬표첨피인문소인식,후피증명시일충Wnt분자적포외억제제,속우sFRP가족.WIF-1가이직접여Wnt분자결합,억제Wnt분자여수체세포막상적Frizzled수체급보조수체LRP5/6형성삼취체복합물,종이억제료신호전도. Wif1 재반마어、조섬、소서화인적신경계통균유표체,삼여조섬신경계통A-P축적분화,영향소서시간세포적형성. Wif1 재배태기소서중추신경계통중표체강렬,제시재배태기신경계통발육중, Wif1 가능대Wnt신호통로활성기착시공특이성적조절작용.Wnt신호통로재척추동물중추신경계통발육중발휘착중요적작용,단인문대 Wif1 재신경계통발육중적공능각지지심소.근거 Wif1 재신경발육중적표체보신식,가이선취합괄적연구시기화부위,연구 Wif1 재신경발육중적공능.
Wnt inhibitor factor-1 (WIF-1) is an extracellular antagonist of Wnts secreted proteins,first characterized as an expressed sequence tag in the human retina.WIF-1 belongs to the secreted Frizzled-related protein (sFRP) class,which can directly bind to Wnt proteins,prevent Wnts from binding to their receptors in vertebrates. Wif1 is expressed in the nervous system of mouse,Xenopus,zebrafish and human.It has been shown that WIF-1 affects the formation of somites in Xenopus embryos and inhibits rod production in retinal histogenesis by binding to Wnt4 in mice.Histological information of Wif1 expression during the development of the central nervous system has been reported in mouse,Xenopus and zebrafish and the strong embryonic expression suggests Wif1 may play an essential role in the spatial and temporal regulation of Wnt signals in development of central nervous system.The Wnt pathway plays a key role in the patterning of the nervous system.However,insights into the function of Wif1 in the development of the central nervous system are rather limited.Selecting suitable stage and target according to the expression pattern may contribute to understanding the function of Wif1.