CAJ | 학술논문

目的探讨内源性阿片肽在创伤性脑损伤发病机制中的作用.方法采用放射免疫分析法(RIA)测定30例全麻颅脑手术患者和30例全麻非颅脑手术患者术前、术后及30例正常人血浆β-内啡肽(β-endorphin,β-EP)和强啡肽A_(1-13)(dynorphin,DynA_(1-13))含量.结果 ①60例手术患者术后血浆β-EP含量显著升高(P<0.01),两组比较差异无统计学意义(P>0.05);②颅脑手术患者术后DynA_(1-13)含量显著升高(P<0.01),与非颅脑手术患者比较差异有统计学意义(P<0.01);③不同部位颅脑手术患者血浆β-EP和DynA_(1-13)含量比较差异无统计学意义(P>0.05).结论内源性阿片肽在创伤性脑损伤病理生理过程中发挥的作用不同.β-EP在机体应激状态时普遍升高,血浆DynA_(1-13)含量是创伤性脑损伤的特异性指标,DynA_(1-13)含量与脑损伤部位无关.
목적 탐토내원성아편태재창상성뇌손상발병궤제중적작용.방법 채용방사면역분석법(RIA)측정30례전마로뇌수술환자화30례전마비로뇌수술환자술전、술후급30례정상인혈장β-내배태(β-endorphin,β-EP)화강배태A_(1-13)(dynorphin,DynA_(1-13))함량.결과 ①60례수술환자술후혈장β-EP함량현저승고(P<0.01),량조비교차이무통계학의의(P>0.05);②로뇌수술환자술후DynA_(1-13)함량현저승고(P<0.01),여비로뇌수술환자비교차이유통계학의의(P<0.01);③불동부위로뇌수술환자혈장β-EP화DynA_(1-13)함량비교차이무통계학의의(P>0.05).결론 내원성아편태재창상성뇌손상병리생리과정중발휘적작용불동.β-EP재궤체응격상태시보편승고,혈장DynA_(1-13)함량시창상성뇌손상적특이성지표,DynA_(1-13)함량여뇌손상부위무관.
Objective To study the effects of endogenous opioid peptides on the pathogenesis of traumatic brain injury. Methods To determine plasma β-endorphin(β-EP) and dynorphin A_(1-13) (DynA_(1-13)) levels in 30 cases of normal human, and 30 cases of general anesthesia craniotomy patients and 30 cases of general anesthesia non-brain surgery before brain surgery and after brain surgery by radioimmunoassay (RIA). Results ①Plasma β-EP levels significantly increased in 60 cases after surgery(P<0.01), two surgery groups showed no significant difference(P>0.05);②After brain surgery, patients' plasma DynA_(1-13) were significantly higher(P<0.01), the two surgery groups were significantly different(P<0.01);③In the patients with different parts of brain surgery, β-EP and DynA_(1-13) levels showed no significant difference(P>0.05). Conclusion In the process of pathophysiology of traumatic brain injury, the endogenous opioid peptides have different effects. In the body's stress state, β-endorphin generally increases, plasma level of DynA_(1-13) is a specific indicator of traumatic brain injury, DynA_(1-13) content has nothing to do with the brain injury site.