国际流行病学传染病学杂志
國際流行病學傳染病學雜誌
국제류행병학전염병학잡지
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY AND INFECTIOUS DISEASE
2011年
5期
336-340
,共5页
RNA,小分子干扰%肝炎,丙型%基因治疗
RNA,小分子榦擾%肝炎,丙型%基因治療
RNA,소분자간우%간염,병형%기인치료
RNA,small interfering%Hepatitis C%Gene therapy
丙型肝炎是由HCV感染引起的严重危害人类健康的传染性疾病,至今尚无特效的防治方法.小干扰RNA(siRNA)作为一种新型基因治疗分子,在RNA干扰(RNAi)抗病毒的研究背景下,也逐渐应用于抑制HCV感染.目前,在研究siRNA对病毒自身基因组的抑制、对宿主相关基因的沉默、病毒逃逸的应对及与固有免疫的关系等方面,取得了大量有意义的研究成果.同时,siRNA抗HCV研究也面临着诸多障碍.此文就siRNA抗HCV的研究作一简要综述.
丙型肝炎是由HCV感染引起的嚴重危害人類健康的傳染性疾病,至今尚無特效的防治方法.小榦擾RNA(siRNA)作為一種新型基因治療分子,在RNA榦擾(RNAi)抗病毒的研究揹景下,也逐漸應用于抑製HCV感染.目前,在研究siRNA對病毒自身基因組的抑製、對宿主相關基因的沉默、病毒逃逸的應對及與固有免疫的關繫等方麵,取得瞭大量有意義的研究成果.同時,siRNA抗HCV研究也麵臨著諸多障礙.此文就siRNA抗HCV的研究作一簡要綜述.
병형간염시유HCV감염인기적엄중위해인류건강적전염성질병,지금상무특효적방치방법.소간우RNA(siRNA)작위일충신형기인치료분자,재RNA간우(RNAi)항병독적연구배경하,야축점응용우억제HCV감염.목전,재연구siRNA대병독자신기인조적억제、대숙주상관기인적침묵、병독도일적응대급여고유면역적관계등방면,취득료대량유의의적연구성과.동시,siRNA항HCV연구야면림착제다장애.차문취siRNA항HCV적연구작일간요종술.
Hepatitis C,which is caused by HCV,is a worldwide epidemic endangering human health,and nowadays there is no specific treatment.As a novel molecule of gene therapy,small interfering RNA (siRNA) has been increasingly used to inhibit HCV infection based on the antiviral effect of RNA interference(RNAi).Some progress has been made,such as the inhibition of HCV rephcation or relevant cellular cofactors by siRNA,the prevention of escape mutants,and the rehtions between siRNA and innate immunity.Meanwhile,researchers are also facing many obstacles.In this paper,studies of inhibition in HCV infection by siRNA were briefly summarized.
