中国实用眼科杂志
中國實用眼科雜誌
중국실용안과잡지
CHINESE JOURNAL OF PRACTICAL OPHTHALMOLOGY
2012年
8期
953-956
,共4页
李青吉%孙丰源%林锦镛%赵堪兴
李青吉%孫豐源%林錦鏞%趙堪興
리청길%손봉원%림금용%조감흥
泪腺多形性腺瘤%复发%临床特征%细胞凋亡%Survivin%Caspase-3
淚腺多形性腺瘤%複髮%臨床特徵%細胞凋亡%Survivin%Caspase-3
루선다형성선류%복발%림상특정%세포조망%Survivin%Caspase-3
Lacrimal gland pleomorphic adenoma%Recurrent%Clinical features%Apoptosis%Survivin%Caspase-3
目的 对复发性多形性腺瘤的临床特征等进行分析并对其表达的相关凋亡因子survivin和caspase-3进行研究.方法 收集2003年1月至2007年1月期间住院的泪腺多形性腺瘤、复发性多形性腺瘤及腺样囊性癌患者的临床资料,对这些患者术后的石蜡包埋标本进行survivin和caspase-3免疫组化染色.结果 复发性多形性腺瘤多表现眶壁骨质破坏及边界不规则的特点；survivin表达方面,复发性多形性腺瘤与初次手术的多形性腺瘤之间差异有统计学意义(P＜0.05),而与腺样囊性癌之间差异则无统计学意义(P＞0.05); caspase-3表达方面,各组之间差异无统计学意义(P＞0.05); Survivin与caspase-3之间呈负相关(r=-0.995,P＜0.05).结论 复发性泪腺多形性腺瘤虽然在病理上表现为良性,但在生物学行为上则是恶性肿瘤的表现,治疗上应多从该肿瘤的恶性生物学行为方面进行考虑；survivin的高表达与caspase-3的低表达可能在泪腺多形性腺瘤的复发中具有重要作用.
目的 對複髮性多形性腺瘤的臨床特徵等進行分析併對其錶達的相關凋亡因子survivin和caspase-3進行研究.方法 收集2003年1月至2007年1月期間住院的淚腺多形性腺瘤、複髮性多形性腺瘤及腺樣囊性癌患者的臨床資料,對這些患者術後的石蠟包埋標本進行survivin和caspase-3免疫組化染色.結果 複髮性多形性腺瘤多錶現眶壁骨質破壞及邊界不規則的特點；survivin錶達方麵,複髮性多形性腺瘤與初次手術的多形性腺瘤之間差異有統計學意義(P＜0.05),而與腺樣囊性癌之間差異則無統計學意義(P＞0.05); caspase-3錶達方麵,各組之間差異無統計學意義(P＞0.05); Survivin與caspase-3之間呈負相關(r=-0.995,P＜0.05).結論 複髮性淚腺多形性腺瘤雖然在病理上錶現為良性,但在生物學行為上則是噁性腫瘤的錶現,治療上應多從該腫瘤的噁性生物學行為方麵進行攷慮；survivin的高錶達與caspase-3的低錶達可能在淚腺多形性腺瘤的複髮中具有重要作用.
목적 대복발성다형성선류적림상특정등진행분석병대기표체적상관조망인자survivin화caspase-3진행연구.방법 수집2003년1월지2007년1월기간주원적루선다형성선류、복발성다형성선류급선양낭성암환자적림상자료,대저사환자술후적석사포매표본진행survivin화caspase-3면역조화염색.결과 복발성다형성선류다표현광벽골질파배급변계불규칙적특점；survivin표체방면,복발성다형성선류여초차수술적다형성선류지간차이유통계학의의(P＜0.05),이여선양낭성암지간차이칙무통계학의의(P＞0.05); caspase-3표체방면,각조지간차이무통계학의의(P＞0.05); Survivin여caspase-3지간정부상관(r=-0.995,P＜0.05).결론 복발성루선다형성선류수연재병리상표현위량성,단재생물학행위상칙시악성종류적표현,치료상응다종해종류적악성생물학행위방면진행고필；survivin적고표체여caspase-3적저표체가능재루선다형성선류적복발중구유중요작용.
Objective To analyze clinical features of recurrent lacrimal gland pleomorphic adenoma and study correlated apoptosis factors-survivin and caspase-3. Methods It was a retrospective case series.Clinical data of lacrimal gland pleomorphic adenomas,recurrent pleomorphic adenomas and adenoid cystic carcinomas were collected from January 2003 to January 2007.All these surgical specimens were studied with immunohistochemical staining of survivin and caspase-3. Results Most recurrent pleomorphic adenomas displayed destruction of orbital wall and irregular boundary.There were statistically significant differences between recurrent pleomorphic adenomas and pleomorphic adenomas (P ＜0.05) while no statistically significant differences between recurrent pleomorphic adenomas and adenoid cystic carcinomas (P ＞0.05) in expression of survivin.And there were no statistically significant differences in expression of caspase-3 (P ＞0.05).The expression of survivin was negatively correlated with caspase-3 (r =-0.995,P ＜0.05). Conclusions Although the recurrent lacrimal gland pleomorphic adenomas are benign in pathology,they display malignant tumors in biological behaviors.We should consider their malignant biological behaviors in the therapy.Both over expression of survivin and descended expression of caspase-3 may play an important role in recurrence of pleomorphic adenomas.
