CAJ | 학술논문

目的探讨伴有5号染色体长臂缺失(5q-)的急性淋巴细胞白血病的临床及实验室特点.方法报道1例伴有5q-的急性淋巴细胞白血病,并对相关文献进行复习.结果患者因腹痛、骨痛就诊.血常规显示白细胞增高、血小板减少.经骨髓穿刺、过氧化物酶染色、流式细胞术免疫分型检测,诊断为急性淋巴细胞白血病(前T细胞型).染色体及荧光免疫杂交检测均发现5q-.应用hyper-CVAD方案化疗曾短暂缓解,复发后应用MEA和hyper-CVAD方案,均无效.通过文献复习发现,5q-在急性淋巴细胞白血病中十分罕见,此类患者5q缺失序列的最小重叠范围位于DNA标记D5S410和D5S436之间,即5q31-33区域.结论急性淋巴细胞白血病中5q-相当罕见,对该类疾病特点仍需进一步研究.
목적 탐토반유5호염색체장비결실(5q-)적급성림파세포백혈병적림상급실험실특점.방법 보도1례반유5q-적급성림파세포백혈병,병대상관문헌진행복습.결과 환자인복통、골통취진.혈상규현시백세포증고、혈소판감소.경골수천자、과양화물매염색、류식세포술면역분형검측,진단위급성림파세포백혈병(전T세포형).염색체급형광면역잡교검측균발현5q-.응용hyper-CVAD방안화료증단잠완해,복발후응용MEA화hyper-CVAD방안,균무효.통과문헌복습발현,5q-재급성림파세포백혈병중십분한견,차류환자5q결실서렬적최소중첩범위위우DNA표기D5S410화D5S436지간,즉5q31-33구역.결론 급성림파세포백혈병중5q-상당한견,대해류질병특점잉수진일보연구.
Objective To introduce the laboratory and clinical characteristics of acute lymphoblastic leukemia accompanied by the karyotypic abnormality of 5q-.Methods Report the diagnosis and treatment of one case of acute lymphoblastic leukemia with 5q- and review the relevant literatures.Results The patient came to the hospital because of bellyache and ostalgia.The blood routine showed a high WBC count and reduced platelets.Bone marrow aspirates examination indicated acute leukemia and by peroxidase staining and flow cytometry test,acute pro-T lymphoblastic leukemia was diagnosed.The karyotype and fluorescence in situ hybridization analysis showed 5q-.The hyper-CVAD regimen induced a temporary remission but it did not work anymore after the relapse nor did the MEA regimen.From the literatures ever reported,the kyryotypic abnormality of 5q- was rarely seen in acute lymphoblastic leukemia.In such cases,the minimal deletion region overlaped between marks of D5S410 and D5S436 corresponding to chromosomal location 5q31-33.Conclusion 5q- is rare in acute lymphoblastic leukemia and more features are still to be found about the kind of disorder.