中华泌尿外科杂志
中華泌尿外科雜誌
중화비뇨외과잡지
CHINESE JOURNAL OF UROLOGY
2012年
9期
692-695
,共4页
张志强%于德新%谢栋栋%苏晓丽%施浩强%王毅%张涛%丁德茂%闵捷%褚晗
張誌彊%于德新%謝棟棟%囌曉麗%施浩彊%王毅%張濤%丁德茂%閔捷%褚晗
장지강%우덕신%사동동%소효려%시호강%왕의%장도%정덕무%민첩%저함
托特罗定%坦索罗辛%膀胱过度活动症%输尿管支架管
託特囉定%坦索囉辛%膀胱過度活動癥%輸尿管支架管
탁특라정%탄색라신%방광과도활동증%수뇨관지가관
Toltcrodin%Tamsulosin%Overactive bladder symptoms%Ureteral stent
目的 观察托特罗定联合坦索罗辛治疗双J管置入后相关症状的效果. 方法 输尿管镜碎石术后留置双J管患者96例,随机分为2组,坦索罗辛组:48例,接受坦索罗辛(0.2 mg1次/d)治疗；联合用药组:48例,接受托特罗定(2 mg2次/d)和坦索罗辛(0.2 mg 1次/d)联合治疗.96例患者随访4周,术前1d及术后4周拔管时完成输尿管相关症状问卷(USSQ)、IPSS及膀胱过度活动症症状评分(OABSS). 结果 96例患者均完成研究.两组术后4周USSQ中尿路症状评分分别为(25.4±4.0)与(15.3±2.9)分,躯体疼痛症状评分分别为(15.0±2.6)与(10.3±2.1)分,总体健康评分分别为(15.4±2.2)与(11.0±1.5)分,工作能力评分分别为(13.0±2.2)与(9.7±1.9)分,性生活质量评分分别为(3.6±1.1)与(2.2±0.9)分；IPSS评分分别为(12.8 ±2.0)与(9.2±1.7)分,OABSS评分分别为(6.7±1.4)与(4.2±1.4)分,组间比较差异均有统计学意义(P＜0.0001). 结论 留置双J输尿管支架管严重影响患者生活质量,托特罗定联合坦索罗辛能明显改善输尿管支架管相关症状,提高患者生活质量.
目的 觀察託特囉定聯閤坦索囉辛治療雙J管置入後相關癥狀的效果. 方法 輸尿管鏡碎石術後留置雙J管患者96例,隨機分為2組,坦索囉辛組:48例,接受坦索囉辛(0.2 mg1次/d)治療；聯閤用藥組:48例,接受託特囉定(2 mg2次/d)和坦索囉辛(0.2 mg 1次/d)聯閤治療.96例患者隨訪4週,術前1d及術後4週拔管時完成輸尿管相關癥狀問捲(USSQ)、IPSS及膀胱過度活動癥癥狀評分(OABSS). 結果 96例患者均完成研究.兩組術後4週USSQ中尿路癥狀評分分彆為(25.4±4.0)與(15.3±2.9)分,軀體疼痛癥狀評分分彆為(15.0±2.6)與(10.3±2.1)分,總體健康評分分彆為(15.4±2.2)與(11.0±1.5)分,工作能力評分分彆為(13.0±2.2)與(9.7±1.9)分,性生活質量評分分彆為(3.6±1.1)與(2.2±0.9)分；IPSS評分分彆為(12.8 ±2.0)與(9.2±1.7)分,OABSS評分分彆為(6.7±1.4)與(4.2±1.4)分,組間比較差異均有統計學意義(P＜0.0001). 結論 留置雙J輸尿管支架管嚴重影響患者生活質量,託特囉定聯閤坦索囉辛能明顯改善輸尿管支架管相關癥狀,提高患者生活質量.
목적 관찰탁특라정연합탄색라신치료쌍J관치입후상관증상적효과. 방법 수뇨관경쇄석술후류치쌍J관환자96례,수궤분위2조,탄색라신조:48례,접수탄색라신(0.2 mg1차/d)치료；연합용약조:48례,접수탁특라정(2 mg2차/d)화탄색라신(0.2 mg 1차/d)연합치료.96례환자수방4주,술전1d급술후4주발관시완성수뇨관상관증상문권(USSQ)、IPSS급방광과도활동증증상평분(OABSS). 결과 96례환자균완성연구.량조술후4주USSQ중뇨로증상평분분별위(25.4±4.0)여(15.3±2.9)분,구체동통증상평분분별위(15.0±2.6)여(10.3±2.1)분,총체건강평분분별위(15.4±2.2)여(11.0±1.5)분,공작능력평분분별위(13.0±2.2)여(9.7±1.9)분,성생활질량평분분별위(3.6±1.1)여(2.2±0.9)분；IPSS평분분별위(12.8 ±2.0)여(9.2±1.7)분,OABSS평분분별위(6.7±1.4)여(4.2±1.4)분,조간비교차이균유통계학의의(P＜0.0001). 결론 류치쌍J수뇨관지가관엄중영향환자생활질량,탁특라정연합탄색라신능명현개선수뇨관지가관상관증상,제고환자생활질량.
Objective To evaluate the effect of combination therapy of tolterodine and tamsulosin in improving symptoms in patients with indwelling double-J ureteral stents.Methods A total of 96 patients underwent placement of a double-J ureteral stent after retrograde ureteroscopy for urinary stone disease,which were prospectively randomized ( random numbers table) into two groups.The tamsulosin group ( n =48) was administered tamsulosin 0.2 mg once daily,the combination group (n =48) was administcred tamsulosin 0.2 mg once daily and tolterodine 2 mg twice daily.All the patients completed a validated Ureteral Stent Symptom Questionnaire (USSQ),the Overactive Bladder Symptom Score (OABSS),the International Prostate Symptom Score (IPSS) one day before he placement and 4 weeks after stent placement of stent.Results The mean urinary symptom index score (25.4 ± 4.0 vs 15.3 ± 2.9,P ＜ 0.0001 ),the mean pain index score (15.0 ±2.6 vs10.3 ±2.1,P ＜0.0001),the mean general health index score (15.4 ±2.2 vs 11.0±1.5,P＜0.0001),the work performance index score (13.0±2.2vs9.7±1.9,P＜0.0001),the sex index score (3.6 ± 1.1 vs 2.2 ± 0.9,P ＜0.0001 ) improved significantly in combination group than those in tamsulosin group.There was a statistically significant difference between tamsulosin group and combination group in the IPSS score ( 12.8 ± 2.0 vs 9.2 ± 1.7,P ＜ 0.0001 ) and OABSS score ( 6.7 ± 1.4 vs 4.2 ± 1.4,P ＜ 0.0001 ) at the 4 weekfollow-up.Conclusions Indwelling ureteral stents have a significant impact on health related quality of life.It is effective for improving symptoms in patients with indwelling double-J ureteral stents by combination therapy with tolterodine and tamsulosin.
