中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2009年
12期
22-24
,共3页
紫癜,过敏性%半胱氨酸蛋白酶抑制剂%β2微球蛋白%血液动力学过程
紫癜,過敏性%半胱氨痠蛋白酶抑製劑%β2微毬蛋白%血液動力學過程
자전,과민성%반광안산단백매억제제%β2미구단백%혈액동역학과정
Purpura,Schoenlein-Henoeh%Cysteine proteinase inhibitors%Beta 2-mieroglobulin%Hemodynamic processes
目的 探讨过敏性紫癜(HSP)患儿血清半胱氨酸蛋白酶抑制剂C(cystatin-C)、β2微球蛋白(B2-MG)及肾血流动力学变化对早期肾损害的临床意义.方法 选取46例HSP患儿(HSP组)和40例健康儿童(对照组).运用ELISA法测定血清cystatin-C,放射免疫法测定血清B2-MG,彩色多普勒超声检测.肾血流动力学变化.结果 HSP组患儿血清cystatin-C[(3.96±1.52)mg/L]及B2-MG[(2.74±0.82)mg/L]均显著高于对照组[(1.67±0.61)mg/L和(1.89±0.47)mg/L],P值均<0.01.HSP组患儿肾血流频谱为高速高阻型,肾主动脉收缩期最大峰值流速[(1.068±0.348)m/s]和阻力指数(0.894±0.125)均高于对照组[(0.859±0.357)m/s和0.726±0.078],P值均<0.05.结论 联合检测血清cystatin-C及肾血流动力学变化能大大提高早期发现肾损害的敏感性.
目的 探討過敏性紫癜(HSP)患兒血清半胱氨痠蛋白酶抑製劑C(cystatin-C)、β2微毬蛋白(B2-MG)及腎血流動力學變化對早期腎損害的臨床意義.方法 選取46例HSP患兒(HSP組)和40例健康兒童(對照組).運用ELISA法測定血清cystatin-C,放射免疫法測定血清B2-MG,綵色多普勒超聲檢測.腎血流動力學變化.結果 HSP組患兒血清cystatin-C[(3.96±1.52)mg/L]及B2-MG[(2.74±0.82)mg/L]均顯著高于對照組[(1.67±0.61)mg/L和(1.89±0.47)mg/L],P值均<0.01.HSP組患兒腎血流頻譜為高速高阻型,腎主動脈收縮期最大峰值流速[(1.068±0.348)m/s]和阻力指數(0.894±0.125)均高于對照組[(0.859±0.357)m/s和0.726±0.078],P值均<0.05.結論 聯閤檢測血清cystatin-C及腎血流動力學變化能大大提高早期髮現腎損害的敏感性.
목적 탐토과민성자전(HSP)환인혈청반광안산단백매억제제C(cystatin-C)、β2미구단백(B2-MG)급신혈류동역학변화대조기신손해적림상의의.방법 선취46례HSP환인(HSP조)화40례건강인동(대조조).운용ELISA법측정혈청cystatin-C,방사면역법측정혈청B2-MG,채색다보륵초성검측.신혈류동역학변화.결과 HSP조환인혈청cystatin-C[(3.96±1.52)mg/L]급B2-MG[(2.74±0.82)mg/L]균현저고우대조조[(1.67±0.61)mg/L화(1.89±0.47)mg/L],P치균<0.01.HSP조환인신혈류빈보위고속고조형,신주동맥수축기최대봉치류속[(1.068±0.348)m/s]화조력지수(0.894±0.125)균고우대조조[(0.859±0.357)m/s화0.726±0.078],P치균<0.05.결론 연합검측혈청cystatin-C급신혈류동역학변화능대대제고조기발현신손해적민감성.
Objective To explore the changes and clinical significance of serum cystatin-C, β2- mieroglobulin (β2-MG) and renal hemodynamic in children with Henoch-Schoenlein purpura(HSP). Method Forty-six patients with HSP are in HSP group, 40 healthy children are in control group. Serum cystatin-C was determined by enzyme-linked immunosorbent assay, β2-MG was detected by radioimmunoassay, renal hemodynamie was detected by colour Doppler ultrasound. Results Serum cystafin-C and β2-MG in HSP group [(3.96±1.52 ), (2.74±0.82)mg/L] were higher than those in control group [(1.67±0.61), (1.89±0.47)mg/L] (P<0.01). Frequenee spectra showed high velocity and resistance, and maximum crest flow rate[(1.068±0.348) m/s] and resistance index (0.894±0.125) in systolic phase of main renal arteries were obviously higher in HSP group than those in control group [(0.859±0.357) m/s and 0.726±0.078] (P<0.05). Conclusions The level of serum cystatin-C and the change of renal hemedynamie can act as the significant indicators of early diagnosis of HSP nephritis.
