CAJ | 학술논문

目的了解上海急慢性乙型肝炎患者的病毒基因型分布概况.方法 2003至2007年入住上海长海医院的62例急性乙型肝炎(AHB)患者和随机抽取的73例同期住院的慢性乙型肝炎(CHB)患者被纳入本研究.对所有患者血清HBV S区基因应用直接基凶测序方法进行基因分型,同时收集肝功能、病毒学指标和相关流行病学资料.对组间均数差异应用t检验,频率差异用x2检验.结果上海地区AHB和CHB的主要病毒基因型为B型、C型,分别为48.4%(30/62)、51.6%(32/62)和26.0%(19/73)、74.0%(54/73),B型在AHB比例明显高于CHB(P<0.05).在流行病学特征和临床转归方面,这两种病毒基囚型在AHB之间差异无统计学意义.C型在CHB中比例明显高于AHB(x2=7.25,P<0.01).AHB组的主要传播途径为多伴侣性接触,为18例,占29.0%;CHB组的主要传播途径为母婴传播,为38例,占52.1%.结论上海地区AHB和CHB主要病毒基因型均为B型和C型,AHB组B型所占比例相对较高,CHB组C型所占比例相对较高,病毒基因型与AHB临床预后无关.
목적 료해상해급만성을형간염환자적병독기인형분포개황.방법 2003지2007년입주상해장해의원적62례급성을형간염(AHB)환자화수궤추취적73례동기주원적만성을형간염(CHB)환자피납입본연구.대소유환자혈청HBV S구기인응용직접기흉측서방법진행기인분형,동시수집간공능、병독학지표화상관류행병학자료.대조간균수차이응용t검험,빈솔차이용x2검험.결과 상해지구AHB화CHB적주요병독기인형위B형、C형,분별위48.4%(30/62)、51.6%(32/62)화26.0%(19/73)、74.0%(54/73),B형재AHB비례명현고우CHB(P<0.05).재류행병학특정화림상전귀방면,저량충병독기수형재AHB지간차이무통계학의의.C형재CHB중비례명현고우AHB(x2=7.25,P<0.01).AHB조적주요전파도경위다반려성접촉,위18례,점29.0%;CHB조적주요전파도경위모영전파,위38례,점52.1%.결론 상해지구AHB화CHB주요병독기인형균위B형화C형,AHB조B형소점비례상대교고,CHB조C형소점비례상대교고,병독기인형여AHB림상예후무관.
Objective To investigate the distribution of genotypes in chronic HBV infection (CHB) and acute HBV infection (AHB) patients in Shanghai. Methods Sixty-two patients with AHB and 73 patients with CHB admitted to ('hanghai Hospital of Shanghai between 2003 and 2007 were studied. Viral genotypes of all the patients were determined by direct gene sequencing.Meanwhile, epidemiological, clinical and biochemical parameters of all patients were collected. Mean values of different groups were compared by t test while frequency was compared by chi square test. Results The major prevalent genotypes in both AHB and CHB patients were genotype B and C (48.4% vs 51.6% in AHB patients and 26.0% vs 74.0% in CHB patients). The proportion of genotype B was higher in AHB patients compared to CHB patients (P= 0.02). Epidemiological factors and clinical outcomes were not statistically different among patients with different viral genotypes. The proportion of genotype C was much higher in CHB patients compared to AHB patients (P=0.006). The main transmission route of AHB was heterosexual interaction which was 18 out of 62 (29.0%), but in CHB patients, it was prenatal transmission which was 38 out of 73 (52.1%). Conclusions In shanghai, the main HBV genotypes in both AHB and CHB patients are genotype B and C. The proportion of genotype B is relatively high in AHB patients while proportion of genotype C is more common in CHB patients. There is no significant relationship between genotypes and the clinical outcomes of AI-IB patients.