CAJ | 학술논문

利用Chiralcel OJ-H和Chiralcel OD-H手性柱对烯唑醇、三唑酮和三唑醇的手性拆分进行了研究,进一步测定了烯唑醇和三唑酮对映体的旋光性质,据此确定了两种农药对映体的绝对构型,在此基础上结合三唑酮转化为三唑醇的还原实验确定了三唑醇4个对映异构体的绝对构型.考察了几种三唑农药在有机溶剂和缓冲溶液中的手性稳定性,其中三唑酮在甲醇、乙醇和水中存在明显的对映体转化行为,而烯唑醇和三唑醇则是手性稳定的,升高温度及碱性环境会加快三唑酮的对映体转化.
이용Chiralcel OJ-H화Chiralcel OD-H수성주대희서순、삼서동화삼서순적수성탁분진행료연구,진일보측정료희서순화삼서동대영체적선광성질,거차학정료량충농약대영체적절대구형,재차기출상결합삼서동전화위삼서순적환원실험학정료삼서순4개대영이구체적절대구형.고찰료궤충삼서농약재유궤용제화완충용액중적수성은정성,기중삼서동재갑순、을순화수중존재명현적대영체전화행위,이희서순화삼서순칙시수성은정적,승고온도급감성배경회가쾌삼서동적대영체전화.
The chiral separation of three triazole pesticides, i.e. diniconazole, triadimefon and triadimenol was studied on a Chiralcel OJ-H and a Chiralcel OD-H HPLC chiral columns. The optical rotation quality of diniconazole and triadimefon enantiomers was measured and the absolute configurations of individual enan-)tiomers) were further concluded. On this basis, the absolute configurations of the four triadimenol stereoisomers were deduced via the reductive experiment of triadimefon to triadimenol. Furthermore, the chiral stability of the three triazole pesticides in organic solvents and buffer solutions was investigated. The results showed the obvious enantiomerization was observed as for triadimefon in methanol, ethanol and water, whereas dinicona-)zole) and triadimefon were chiral stable in organic solvents and water. The enantiomerization of triadimefon would be accelerated at higher temperature and in alkaline media.