CAJ | 학술논문

为避免芳香族聚氨酯在体内降解时产生有毒物质,选用生物相容性良好的脂肪族聚氨酯(PU)与生物活性的羟基磷灰石(HA)为原料,通过原位聚合法制备了脂肪族PU/HA组织工程用多孔支架,并采用SEM、IR和力学试验等方法对多孔支架的形貌和性能进行了表征,进一步研究了发泡剂(水)用量和HA含量对支架泡孔结构和力学强度的影响.结果表明,当发泡剂用量为1%～1.5%(质量分数)时制得的多孔PU/HA复合支架材料孔隙之间相互贯通,孔径范围分布在300～800μm,大孔壁上分布着孔径为50～200μm的小孔,孔隙率达80%以上.随HA含量增加,支架抗压强度和弹性模量显著上升.综合考虑HA的增强效果和组织工程支架的孔隙结构,本体系中HA的最佳添加量为40%(质量分数),发泡剂的最佳用量为1%(质量分数).
위피면방향족취안지재체내강해시산생유독물질,선용생물상용성량호적지방족취안지(PU)여생물활성적간기린회석(HA)위원료,통과원위취합법제비료지방족PU/HA조직공정용다공지가,병채용SEM、IR화역학시험등방법대다공지가적형모화성능진행료표정,진일보연구료발포제(수)용량화HA함량대지가포공결구화역학강도적영향.결과표명,당발포제용량위1%～1.5%(질량분수)시제득적다공PU/HA복합지가재료공극지간상호관통,공경범위분포재300～800μm,대공벽상분포착공경위50～200μm적소공,공극솔체80%이상.수HA함량증가,지가항압강도화탄성모량현저상승.종합고필HA적증강효과화조직공정지가적공극결구,본체계중HA적최가첨가량위40%(질량분수),발포제적최가용량위1%(질량분수).
In order to avoid toxic degradation products of aromatic polyurethanes in vivo,aliphatic polyurethanes with good biocompatibility and bioactive hydroxyapatite were selected to fabricate porous PU/HA scaffolds for tissue engineering by in situ polymerization.The morphology and properties of the scaffolds were characterized by SEM,IR,and mechanical testing.The effects of the amount of blowing agent(water) and HA content on the pore structure and mechanical strength of scaffolds were investigated.The results indicate that when adding 1wt%-1.5wt% blowing agent into PU,the scaffolds possess interconnected porous structure with a pore size mainly ranging from 300 to 800μm,and 50-200μm micropores existed on the pores' walls,the porosity of the scaffolds is more than 80%.The compressive strength and modulus of the composite scaffolds show higher enhancement with increasing HA content.Considering comprehensively the reinforcing effect of the HA filler and the open porous structure for tissue engineering scaffold,in this system,the optimal addition of HA particles in polyurethane can be 40wt% and the optimal amount of blowing agent can be 1wt%.