CAJ | 학술논문

通过人工发酵培养,从南海红树林内源真菌Fusarium sp.ZZF60的培养液中分离得到:1种新蒽醌衍生物,6,8-二甲氧基-1-甲基-2-(3-氧丁基)蒽醌(1),以及5种已知化合物:7-羟基-3-(4-甲氧基苯基)苯并-γ-吡喃酮(2),2,4-二羟基-6-[(1'E,3'E)-1', 3'-戊二烯基]苯甲醛(3),(E)-4-羟基肉桂酸甲酯(4),4-(4-羟基苯基)-2-丁醇(5),4-羟基苯甲酸(6).它们的结构通过MS、NMR等波谱分析推导确定.初步药理活性显示,化合物1抑制体外培养人喉癌细胞Hep2和人肝癌细胞HepG2的IC_(50)分别为16和23 μmol/L.
통과인공발효배양,종남해홍수림내원진균Fusarium sp.ZZF60적배양액중분리득도:1충신은곤연생물,6,8-이갑양기-1-갑기-2-(3-양정기)은곤(1),이급5충이지화합물:7-간기-3-(4-갑양기분기)분병-γ-필남동(2),2,4-이간기-6-[(1'E,3'E)-1', 3'-무이희기]분갑철(3),(E)-4-간기육계산갑지(4),4-(4-간기분기)-2-정순(5),4-간기분갑산(6).타문적결구통과MS、NMR등파보분석추도학정.초보약리활성현시,화합물1억제체외배양인후암세포Hep2화인간암세포HepG2적IC_(50)분별위16화23 μmol/L.
A new anthraquinone derivative, 6,8-dimethoxy-1-methyl-2-(3-oxobutyl) anthrakunthone(1), together with five known compounds, 7-hydroxy-3-(4-methoxyphenyl)-chromen-4-one(2), 2,4-dihydroxy-6-[(1'E,3'E)-penta-1',3'-dienyl]-benzaldehyde(3), (E)-4-hydroxycinnamic acid methyl ester(4), 4-(4-hydroxyphenyl)-butan-2-ol(5), and 4-hydroxybenzoic acid(6), were isolated from the marine mangrove endophytic fungus Fusarium sp.ZZF60 from the South China Sea. Their structures were elucidated by spectral data of IR, MS and NMR. In the preliminary bioassay, compound 1 showed cytotoxicity towards Hep2 and HepG2 with IC_(50) values of 16 μmol/L and 23 μmol/L, respectively.