CAJ | 학술논문

目的评价复方甘草酸苷预防抗结核药物对肝损害的临床作用,观察其疗效、安全性及可靠性.方法 2009年1月-2010年11月期间我院收治的460例初治肺结核病患者,分为观察组260例(抗结核药物+复方甘草酸苷)和对照组200例(抗结核药物+肝泰乐),观察两组药物性肝炎的发病情况.结果观察组发生5例药物性肝炎,对照组发生20例药物性肝炎,其中18例发生于强化期.两组药物性肝炎的发生率分别为1.9%和10%,观察组发生率明显低于对照组.结论复方甘草酸苷与抗结核药物联用可以明显降低抗结核药物性肝炎的发生,效果肯定,对完成整疗程及预防耐药结核病的发生以及提高治愈率有重要意义.
목적 평개복방감초산감예방항결핵약물대간손해적림상작용,관찰기료효、안전성급가고성.방법 2009년1월-2010년11월기간아원수치적460례초치폐결핵병환자,분위관찰조260례(항결핵약물+복방감초산감)화대조조200례(항결핵약물+간태악),관찰량조약물성간염적발병정황.결과 관찰조발생5례약물성간염,대조조발생20례약물성간염,기중18례발생우강화기.량조약물성간염적발생솔분별위1.9%화10%,관찰조발생솔명현저우대조조.결론 복방감초산감여항결핵약물련용가이명현강저항결핵약물성간염적발생,효과긍정,대완성정료정급예방내약결핵병적발생이급제고치유솔유중요의의.
Objective To evaluate the clinical effect of compound glycyrrhizin in the prevention of liver damage induced by antituberculosis drugs and to observe the efficacy, safety and reliability of the compound. Methods 460 patients with pulmonary tuberculosis who had been hospitalized during the period of January 2009 to November 2010 were assigned to receive antituberculosis drugs plus either glycyrrhizin (study group, 260 patients) or glucurolactone (control group, 200 patients). The incidence of drug-induced hepatitis was observed in the two groups. Results Drug-induced hepatitis occurred in 5 patients in the study group and 20 in the control group. 18 of 25 cases developed in the intensified period of treatment. The incidence of drug-induced hepatitis was significantly lower in the study group than in the control group(1.9% vs 10%). Conclusions Glycyrrhizin combined with antituberculosis drugs can significantly reduce the incidence of antituberculosis drug-induced hepatitis, which has important significance in the completion of the entire course of treatment, prevention of the occurrence of drug-resistant tuberculosis,and enhancement of the curative rate.