中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2009年
5期
603-605
,共3页
肝炎,乙型,慢性%胰岛素抗药性
肝炎,乙型,慢性%胰島素抗藥性
간염,을형,만성%이도소항약성
Hepatitis B,chronic%Insulin resistance
目的 探讨慢性乙型肝炎(CHB)患者胰岛素抵抗指数(HOMA-IR)与临床及病理特点的关系.方法 对80例CHB患者进行血清谷丙转氨酶(ALT)、乙肝病毒载量(HBV DNA)及HOMA-IR的检测,并将其与肝组织病理进行相关性分析.结果 胰岛素抵抗(IR)随着炎症活动度、纤维化程度的递增而加重.胰岛素水平(FINS)与HOMA-IR在G3级(15.24±7.41,3.51±1.91)高于G2级(10.33±6.28,2.25±1.39);在S3期(16.65±6.46,3.79±1.50)高于S2期(9.06±4.61,2.02±1.11).HOMA-IR与年龄、ALT呈正相关(r=0.273,0.224,P<0.05).结论 CHB患者IR的发生、发展与年龄、肝组织炎症活动度和纤维化程度密切相关.
目的 探討慢性乙型肝炎(CHB)患者胰島素牴抗指數(HOMA-IR)與臨床及病理特點的關繫.方法 對80例CHB患者進行血清穀丙轉氨酶(ALT)、乙肝病毒載量(HBV DNA)及HOMA-IR的檢測,併將其與肝組織病理進行相關性分析.結果 胰島素牴抗(IR)隨著炎癥活動度、纖維化程度的遞增而加重.胰島素水平(FINS)與HOMA-IR在G3級(15.24±7.41,3.51±1.91)高于G2級(10.33±6.28,2.25±1.39);在S3期(16.65±6.46,3.79±1.50)高于S2期(9.06±4.61,2.02±1.11).HOMA-IR與年齡、ALT呈正相關(r=0.273,0.224,P<0.05).結論 CHB患者IR的髮生、髮展與年齡、肝組織炎癥活動度和纖維化程度密切相關.
목적 탐토만성을형간염(CHB)환자이도소저항지수(HOMA-IR)여림상급병리특점적관계.방법 대80례CHB환자진행혈청곡병전안매(ALT)、을간병독재량(HBV DNA)급HOMA-IR적검측,병장기여간조직병리진행상관성분석.결과 이도소저항(IR)수착염증활동도、섬유화정도적체증이가중.이도소수평(FINS)여HOMA-IR재G3급(15.24±7.41,3.51±1.91)고우G2급(10.33±6.28,2.25±1.39);재S3기(16.65±6.46,3.79±1.50)고우S2기(9.06±4.61,2.02±1.11).HOMA-IR여년령、ALT정정상관(r=0.273,0.224,P<0.05).결론 CHB환자IR적발생、발전여년령、간조직염증활동도화섬유화정도밀절상관.
Objective To investigate the relationship between insulin resistance index (HOMA-IR) and the clinical pathology fea-tures in chronic hepatitis B(CHB) patients. Methods ALT and hepatitis B virus loading level and HOMA-IR were measured in 80 CHB pa-tients. Correlation analysis was performed with pathological features of liver tissue. Result Insulin resistance(IR) was much more obvious in patients with severer degree of liver inflammation and fibrosis . HOMA-IR and the insulin level of CHB patients in G3 grade(15.24±7.41,3.51 ± 1.91) and S3 stage (16.65±6. 46,3.79 ± 1.50) were higher than those in G2 grade (10.33 ± 6.28,2.25 ± 1.39) and S2 stage(9.06 ± 4.61,2.02 ± 1.11). The HOMA-IR was positive correlated with the level of age and ALT. Conclusion The development of IR in CHB patients was correlated with age and the degree of liver inflammation and fibrosis.
