北京市男男性行为者HIV新发感染率及影响因素研究
북경시남남성행위자HIV신발감염솔급영향인소연구
Study on the incidence of HIV and associated risk factors through a prospective cohort among men who have sex with men in Beijing, China
  • 万方数据
    中华流行病学杂志 중화류행병학잡지
    CHINESE JOURNAL OF EPIDEMIOLOGY
    2012年 7期 663-666 ,共4页

    李东亮%高彦杰%于明润%杨雪盈%李书明%徐杰%刘英杰%姜树林%张政%肖冬%闫莉%姜桂艳%王红萍%周振海%阮玉华%邵一鸣%罗凤基

    리동량%고언걸%우명윤%양설영%리서명%서걸%류영걸%강수림%장정%초동%염리%강계염%왕홍평%주진해%원옥화%소일명%라봉기

    男男性行为者%艾滋病病毒%新发感染率%影响因素 男男性行為者%艾滋病病毒%新髮感染率%影響因素
    남남성행위자%애자병병독%신발감염솔%영향인소
    Men who have sex with men%HIV%Incidence%Influencing factors
    目的 了解北京市男男性行为者(MSM)HIV血清抗体阳转率的动态变化情况及影响因素.方法 2009年8-12月在北京市招募962名MSM,其中809名HIV阴性进入队列,每6个月随访检测HIV抗体,并进行体检和行为学问卷调查.结果 在招募的962名MSM中,HIV感染率为6.34％(61/962).对809名HIV阴性者在第6、12和18个月随访时,队列保持率分别为95.1％(769/809)、85.5％( 692/809)、71.0％ (574/809)；HIV血清抗体阳转者分别为19、29和17例；HIV新发感染率分别为5.47/100人年、12.37/100人年、6.86/100人年.18个月随访期间的HIV新发感染率为7.59/100人年.多因素Cox回归模型分析显示,年龄≤25岁(HR=2.32,95％CI:1.39 ～3.87)、认识圈内的朋友数＞8个(HR=2.50,95％CI:1.49～4.20)、月经济收入＜2000元(HR=1.76,95％CI:1.06～2.95)、最近6个月男男性行为人数＞4人(HR=3.50,95％CI:2.11 ～5.81)、体检包皮为包茎或包皮过长或较长者(HR=2.47,95％CI:1.50～4.07)和梅毒检测结果阳性(HR=2.62,95％CI:1.53～4.49)同HIV新发感染的差异有统计学意义.结论 北京市MSM中HIV新发感染率较高,提示该人群中HIV在快速传播.
    목적 료해북경시남남성행위자(MSM)HIV혈청항체양전솔적동태변화정황급영향인소.방법 2009년8-12월재북경시초모962명MSM,기중809명HIV음성진입대렬,매6개월수방검측HIV항체,병진행체검화행위학문권조사.결과 재초모적962명MSM중,HIV감염솔위6.34％(61/962).대809명HIV음성자재제6、12화18개월수방시,대렬보지솔분별위95.1％(769/809)、85.5％( 692/809)、71.0％ (574/809)；HIV혈청항체양전자분별위19、29화17례；HIV신발감염솔분별위5.47/100인년、12.37/100인년、6.86/100인년.18개월수방기간적HIV신발감염솔위7.59/100인년.다인소Cox회귀모형분석현시,년령≤25세(HR=2.32,95％CI:1.39 ～3.87)、인식권내적붕우수＞8개(HR=2.50,95％CI:1.49～4.20)、월경제수입＜2000원(HR=1.76,95％CI:1.06～2.95)、최근6개월남남성행위인수＞4인(HR=3.50,95％CI:2.11 ～5.81)、체검포피위포경혹포피과장혹교장자(HR=2.47,95％CI:1.50～4.07)화매독검측결과양성(HR=2.62,95％CI:1.53～4.49)동HIV신발감염적차이유통계학의의.결론 북경시MSM중HIV신발감염솔교고,제시해인군중HIV재쾌속전파.
    Objective To investigate the dynamic change and associated risk factors of HIV sero-conversion rate in Beijing.Methods 809 sero-negative men who have sex with men (MSM) were recruited in the cohort from August to December in 2009.HIV sero-antibody,medicinal examination and behavior questionnaire interview were carried out every six months.Results 962 MSM with overall baseline prevalence of HIV infection as 6.34％ (61/962) together with 809 seronegative MSM,were enrolled in the cohort.Of the 809 sero-negative participants,95.1％ (769/809),85.5％ ( 692/809 ) and 71.0％ ( 574/809 ) of them were retained in the 6-month,12-month and 18- month follow-up visits,with 19,29 and 17 of them became HIV sero-conversion at 6-month,12-month,and 18-month follow-up visits and the HIV incidence rates appeared to be 5.47,12.37 and 6.86 per 100 person-years respectively.The HIV incidence was 7.59 per 100 person-years in the 18 months follow-up visit.Factors including:younger than 25-years old (HR =2.32,95％CI:1.39-3.87),having more than 8 MSM partners (HR=2.50,95％CI:1.49-4.20),less than RMB 2000 Yuan every month income (HR=1.76,95％CI:1.06-2.95 ),having more than 4 homosexual partners in the last six months (HR=3.50,95％ CI:2.11 -5.81 ),showing phimosis and redundant prepuce (HR=2.47,95％ CI:1.50-4.07 ) as well as positive syphilis test (HR=2.62,95％CI:1.53-4.49) etc.,were significantly associated with HIV incidence.Conclusion High HIV incidence was shown among MSM in Beijing and had spread fast in this population,calling for more favorable prevention measures to be taken.
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