中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2011年
2期
154-157
,共4页
陈忠平%刘江华%姜德咏%张入铭%蒋苏平
陳忠平%劉江華%薑德詠%張入銘%蔣囌平
진충평%류강화%강덕영%장입명%장소평
普罗布可/药理学%糖尿病视网膜病变/病理学/代谢%氧化性应激%黄斑水肿
普囉佈可/藥理學%糖尿病視網膜病變/病理學/代謝%氧化性應激%黃斑水腫
보라포가/약이학%당뇨병시망막병변/병이학/대사%양화성응격%황반수종
Probucol/PD%Diabetic retinopathy/PA/ME%Oxidative stress%Macular edema
目的 研究普罗布考对非增殖型糖尿病变视网膜病变(NPDR)患者血脂、血清总抗氧化能力(TAOC)、丙二醛(MDA)浓度、超氧化物歧化酶(SOD)水平及黄斑水肿的影响,为普罗布考防治早期DR提供临床依据.方法 纳入66例伴NPDR的2型糖尿病患者127眼,随机分为对照组和治疗组:对照组进行强化降血糖、血压治疗,治疗组在强化治疗基础上加用普罗布考0.375 g,2次/d,口服,总疗程为12月.治疗前后两组患者均进行了血脂、氧化应激指标及眼底荧光血管造影检查.结果 共有62例120眼完成研究,普罗布考组患者总胆固醇(TC)[(3.6±0.58)mmol/L VS(4.71±0.61)mmol/L,t=7.65,P＜0.01]、甘油三酯(TG)[(1.07±0.35)mmol/L VS(1.23±0.43)mmol/L,t=2.02,P＜0.05]、低密度脂蛋白胆固醇(LDLC)[(2.0±0.47)mmol/LVS(2.55±0.56)mmol/L,t=4.18,P＜0.01]及丙二醛(MDA)[(10.35±2.97)nmol/L VS(14.83±2.75)nmol/L,t=6.18,P＜0.01]水平降低,患者总抗氧化能力(TAOC)[(19.25±4.11)u/ml VS(16.63±3.27)u/ml,t=3.57,P＜0.01]及超氧化物歧化酶(SOD)[(94.52±10.28)u/ml VS(75.37±9.87)u/ml,t=8.62,P＜0.01]水平显著提高,且患者眼底黄斑水肿有明显减轻(x2=4.219,P＜0.05).结论 普罗布考对于NDPR患者除了降脂作用外,还具有明显的抗氧化作用,显著降低患者黄斑水肿发生率,提示普罗布考对NDPR患者具有一定的治疗作用.
目的 研究普囉佈攷對非增殖型糖尿病變視網膜病變(NPDR)患者血脂、血清總抗氧化能力(TAOC)、丙二醛(MDA)濃度、超氧化物歧化酶(SOD)水平及黃斑水腫的影響,為普囉佈攷防治早期DR提供臨床依據.方法 納入66例伴NPDR的2型糖尿病患者127眼,隨機分為對照組和治療組:對照組進行彊化降血糖、血壓治療,治療組在彊化治療基礎上加用普囉佈攷0.375 g,2次/d,口服,總療程為12月.治療前後兩組患者均進行瞭血脂、氧化應激指標及眼底熒光血管造影檢查.結果 共有62例120眼完成研究,普囉佈攷組患者總膽固醇(TC)[(3.6±0.58)mmol/L VS(4.71±0.61)mmol/L,t=7.65,P＜0.01]、甘油三酯(TG)[(1.07±0.35)mmol/L VS(1.23±0.43)mmol/L,t=2.02,P＜0.05]、低密度脂蛋白膽固醇(LDLC)[(2.0±0.47)mmol/LVS(2.55±0.56)mmol/L,t=4.18,P＜0.01]及丙二醛(MDA)[(10.35±2.97)nmol/L VS(14.83±2.75)nmol/L,t=6.18,P＜0.01]水平降低,患者總抗氧化能力(TAOC)[(19.25±4.11)u/ml VS(16.63±3.27)u/ml,t=3.57,P＜0.01]及超氧化物歧化酶(SOD)[(94.52±10.28)u/ml VS(75.37±9.87)u/ml,t=8.62,P＜0.01]水平顯著提高,且患者眼底黃斑水腫有明顯減輕(x2=4.219,P＜0.05).結論 普囉佈攷對于NDPR患者除瞭降脂作用外,還具有明顯的抗氧化作用,顯著降低患者黃斑水腫髮生率,提示普囉佈攷對NDPR患者具有一定的治療作用.
목적 연구보라포고대비증식형당뇨병변시망막병변(NPDR)환자혈지、혈청총항양화능력(TAOC)、병이철(MDA)농도、초양화물기화매(SOD)수평급황반수종적영향,위보라포고방치조기DR제공림상의거.방법 납입66례반NPDR적2형당뇨병환자127안,수궤분위대조조화치료조:대조조진행강화강혈당、혈압치료,치료조재강화치료기출상가용보라포고0.375 g,2차/d,구복,총료정위12월.치료전후량조환자균진행료혈지、양화응격지표급안저형광혈관조영검사.결과 공유62례120안완성연구,보라포고조환자총담고순(TC)[(3.6±0.58)mmol/L VS(4.71±0.61)mmol/L,t=7.65,P＜0.01]、감유삼지(TG)[(1.07±0.35)mmol/L VS(1.23±0.43)mmol/L,t=2.02,P＜0.05]、저밀도지단백담고순(LDLC)[(2.0±0.47)mmol/LVS(2.55±0.56)mmol/L,t=4.18,P＜0.01]급병이철(MDA)[(10.35±2.97)nmol/L VS(14.83±2.75)nmol/L,t=6.18,P＜0.01]수평강저,환자총항양화능력(TAOC)[(19.25±4.11)u/ml VS(16.63±3.27)u/ml,t=3.57,P＜0.01]급초양화물기화매(SOD)[(94.52±10.28)u/ml VS(75.37±9.87)u/ml,t=8.62,P＜0.01]수평현저제고,차환자안저황반수종유명현감경(x2=4.219,P＜0.05).결론 보라포고대우NDPR환자제료강지작용외,환구유명현적항양화작용,현저강저환자황반수종발생솔,제시보라포고대NDPR환자구유일정적치료작용.
Objective To study the influence of probucol on the diabetic mellitus patients with non-proliferative diabetic retinopathy (NPDR) about blood lipids,serum level of the total antioxidant capacity (TAOC),malondialdehyde (MDA),superoxide dismutase (SOD) and macular edema,so as to provide clinical basis for the prevention and treatment of early DR by probucol.Methods 66 type 2 diabetes patients with 127 NPDR eyes were included.Patients were random divided into control and treatment groups,the control group was treated by intensive therapy of blood glucose and blood pressure control,and the treatment group was treated with the intensive therapy and probucol 0.375g,2 times a day for 12 months.Before and after treatment,the blood lipids,oxidative stress indicators and fundus fluorescein angiography in both groups had been determined.Results 62 cases with 120 eyes were enrolled in this study.Probucol obviously decreased levels of total cholesterol (TC) [ (3.6 ± 0.58) mmol/L VS (4.71 ± 0.61)mmol/L,t = 7.65,P ＜ 0.01 ],triglyceride (TG) [ (1.07 ± 0.35) mmol/L VS (1.23 ± 0.43) mmol/L,t = 2.02,P ＜ 0.05 ],low density lipoprotein cholesterol (LDLC) [ (2.0 ± 0.47) mmol/L VS (2.55 ±0.56)mmol/L,t =4.18,P ＜0.01] and MDA[ (10.35 ±2.97)nmol/L VS (14.83 ±2.75)nmol/L,t =6.18,P ＜0.01] in plasma of the patients.Levels of TAOC [(19.25±4.11)u/ml VS (16.63 ±3.27)u/ml,t =3.57,P ＜0.01 ]and SOD[ (94.52 ± 10.28)u/ml VS (75.37 ± 9.87) u/ml,t =8.62,P ＜0.01]were significantly improved in the probucol group,and the macular edema was significantly reduced in patients of the probucol group(x2 =4.219,P ＜0.05).Conclusion Probucol regulated serum lipids,and it had the apparent action of antioxidant,and it decreased the incidence of macular edema.Probucol had a therapeutic effect in patients with NDPR.
