CAJ | 학술논문

目的观察强直性脊柱炎(AS)患者外周血清白介素-1β(IL-1β)、白介素-2(IL-2)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、红细胞沉降率(ESR)、C反应蛋白(CRP)、免疫球蛋白(IgA、IgG、IgM)水平,并分析它们与强直性脊柱炎疾病活动指数(BASDAI)相关性.方法测定45例AS患者及30例健康体检者的IL-1β、2、6及TNF-α,CRP、IgA、IgG、IgM、ESR水平.以Bath强直性脊柱炎疾病活动指数(BASDAI)评定AS患者疾病活动性,取BASDAI中位数将患者分为活动组及非活动组,比较AS患者与对照组,活动组与非活动组各实验指标,分析它们与BASDAI的相关性.结果 AS患者ESR、CRP、IgA、IgM、IgG、IL-1 β、IL-2、IL-6及TNF-α水平与对照组之间差异有统计学意义(P<0.05).AS患者活动组CRP、IL-2与IL-6较非活动组差异有统计学意义(P<0.05).AS患者CRP与IL-6,IL-2与IL-6,IgA与IgG两两之间成正相关,但只有IL-2、IL-6及CRP与BASDAI之间成正相关.结论 IL-2、IL-6与CRP可作为AS疾病活动性的参考指标.
목적 관찰강직성척주염(AS)환자외주혈청백개소-1β(IL-1β)、백개소-2(IL-2)、백개소-6(IL-6)、종류배사인자-α(TNF-α)、홍세포침강솔(ESR)、C반응단백(CRP)、면역구단백(IgA、IgG、IgM)수평,병분석타문여강직성척주염질병활동지수(BASDAI)상관성.방법 측정45례AS환자급30례건강체검자적IL-1β、2、6급TNF-α,CRP、IgA、IgG、IgM、ESR수평.이Bath강직성척주염질병활동지수(BASDAI)평정AS환자질병활동성,취BASDAI중위수장환자분위활동조급비활동조,비교AS환자여대조조,활동조여비활동조각실험지표,분석타문여BASDAI적상관성.결과 AS환자ESR、CRP、IgA、IgM、IgG、IL-1 β、IL-2、IL-6급TNF-α수평여대조조지간차이유통계학의의(P<0.05).AS환자활동조CRP、IL-2여IL-6교비활동조차이유통계학의의(P<0.05).AS환자CRP여IL-6,IL-2여IL-6,IgA여IgG량량지간성정상관,단지유IL-2、IL-6급CRP여BASDAI지간성정상관.결론 IL-2、IL-6여CRP가작위AS질병활동성적삼고지표.
Objective To investigate the significance of serum interleukin-1β,interleukin-2,interleukin-6,TNF-α,erythrocyte sedimentation rate(ESR),c-reactive protein(CRP),IgA,IgG and IgM in patients with ankylosing spondylitis(AS),and to analyze their relationship with the Bath ankylosing spondylitis disease activity index (BASDAI). Methods Participants of this study included 45 AS patients(patient group)and 30 healthy subjects (control group).The patient group was further divided into an active subgroup and an inactive subgroup based on the disease activity assessed by using BASDAI.Then serum levels of IL-1β,IL-2,IL-6,TNF-α,ESR,CRP,IgA,IgC and IgM were tested in all the subjects,and the values were compared between different groups.In addition,the relationship between various parameters and those with BASDAI were also evaluated. Results The serum levels of ESR,CRP,IgA,lgM,IgG,IL-1β,IL-2,IL-6 and TNF-α in patients with AS were significantly higher than those in the healthy controls(P<0.05).The serum level of CRP,IL-2 and IL-6 were significantly different between the active and inactive subgroups(P<0.05).There was a positive correlation between CRP and IL-6,IL-6 and IL-2,as well as IgA and IgG levels.The IL-2,IL-6 and CRP levels were positive correlated with BASDAI.Conclusion It was suggested that the serum levels of IL-2,IL-6 and CRP can be used to assess the disease activity in patients with AS.