乙型肝炎病毒%因素分析,统计学%乙型肝炎病毒相关性肾炎
乙型肝炎病毒%因素分析,統計學%乙型肝炎病毒相關性腎炎
을형간염병독%인소분석,통계학%을형간염병독상관성신염
Hepatitis B Virus%Factors analysis,statistical%Hepatitis B virus associated glomerulonephritis
目的 研究乙型肝炎病毒相关性肾炎(HBV-GN)的相关因素.方法 采用回顾性病例对照研究.用Logistic回归对86例HBV-GN患者及135例非HBV-GN慢性HBV感染者进行比较.结果 单因素分析结果显示,HBV-GN与男性(OR 2.79,95%CI 1.48～5.25,P=0.001)、HBeAg阳性(OR 2.60,95%CI 1.49～4.53,P=0.001)、HBV复制(OR 3.63,95%CI1.80～7.33,P＜0.01)、肝硬化(OR 4.58,95%CI 1.41～14.91,P=0.011)及谷丙转氨酶(ALT)升高(OR 2.53,95%CI 1.42～4.51,P=0.002)相关.多因素分析结果显示,HBV-GN与男性(OR2.21,95%CI 1.12～4.33,P=0.022)、HBV复制(OR 2.77,95%CI 1.28～5.97,P=0.01)、肝硬化(OR 4.55,95%CI 1.29～16.10,P=0.019)及ALT升高(OR 1.96,95%CI 1.04～3.69,P=0.037)相关.HBV-GN中,与IgA肾病型(HBV-IgAN)比较,单因素分析结果显示,经典型HBVGN(膜性肾病或膜增生性肾炎型)与男性(OR 5.24,95%CI1.64～16.81,P=0.005)、HBV复制(OR 8.02,95%CI 2.15～29.84,P=0.002)及ALT升高(OR 3.10,95%CI 1.00～9.67,P=0.051)相关;多因素分析结果显示,仅与男性(OR 6.51,95%CI 1.76～24.11,P=0.005)及HBV复制(OR 7.22,95%CI 1.68～30.97,P=0.008)相关.结论 男性、HBV复制、肝硬化及ALT升高都可能是HBV-GN的易患因素.与HBV-IgAN比较,经典型HBV-GN与病毒复制及男性更相关,两者可能有不同的病理机制.
目的 研究乙型肝炎病毒相關性腎炎(HBV-GN)的相關因素.方法 採用迴顧性病例對照研究.用Logistic迴歸對86例HBV-GN患者及135例非HBV-GN慢性HBV感染者進行比較.結果 單因素分析結果顯示,HBV-GN與男性(OR 2.79,95%CI 1.48～5.25,P=0.001)、HBeAg暘性(OR 2.60,95%CI 1.49～4.53,P=0.001)、HBV複製(OR 3.63,95%CI1.80～7.33,P＜0.01)、肝硬化(OR 4.58,95%CI 1.41～14.91,P=0.011)及穀丙轉氨酶(ALT)升高(OR 2.53,95%CI 1.42～4.51,P=0.002)相關.多因素分析結果顯示,HBV-GN與男性(OR2.21,95%CI 1.12～4.33,P=0.022)、HBV複製(OR 2.77,95%CI 1.28～5.97,P=0.01)、肝硬化(OR 4.55,95%CI 1.29～16.10,P=0.019)及ALT升高(OR 1.96,95%CI 1.04～3.69,P=0.037)相關.HBV-GN中,與IgA腎病型(HBV-IgAN)比較,單因素分析結果顯示,經典型HBVGN(膜性腎病或膜增生性腎炎型)與男性(OR 5.24,95%CI1.64～16.81,P=0.005)、HBV複製(OR 8.02,95%CI 2.15～29.84,P=0.002)及ALT升高(OR 3.10,95%CI 1.00～9.67,P=0.051)相關;多因素分析結果顯示,僅與男性(OR 6.51,95%CI 1.76～24.11,P=0.005)及HBV複製(OR 7.22,95%CI 1.68～30.97,P=0.008)相關.結論 男性、HBV複製、肝硬化及ALT升高都可能是HBV-GN的易患因素.與HBV-IgAN比較,經典型HBV-GN與病毒複製及男性更相關,兩者可能有不同的病理機製.
목적 연구을형간염병독상관성신염(HBV-GN)적상관인소.방법 채용회고성병례대조연구.용Logistic회귀대86례HBV-GN환자급135례비HBV-GN만성HBV감염자진행비교.결과 단인소분석결과현시,HBV-GN여남성(OR 2.79,95%CI 1.48～5.25,P=0.001)、HBeAg양성(OR 2.60,95%CI 1.49～4.53,P=0.001)、HBV복제(OR 3.63,95%CI1.80～7.33,P＜0.01)、간경화(OR 4.58,95%CI 1.41～14.91,P=0.011)급곡병전안매(ALT)승고(OR 2.53,95%CI 1.42～4.51,P=0.002)상관.다인소분석결과현시,HBV-GN여남성(OR2.21,95%CI 1.12～4.33,P=0.022)、HBV복제(OR 2.77,95%CI 1.28～5.97,P=0.01)、간경화(OR 4.55,95%CI 1.29～16.10,P=0.019)급ALT승고(OR 1.96,95%CI 1.04～3.69,P=0.037)상관.HBV-GN중,여IgA신병형(HBV-IgAN)비교,단인소분석결과현시,경전형HBVGN(막성신병혹막증생성신염형)여남성(OR 5.24,95%CI1.64～16.81,P=0.005)、HBV복제(OR 8.02,95%CI 2.15～29.84,P=0.002)급ALT승고(OR 3.10,95%CI 1.00～9.67,P=0.051)상관;다인소분석결과현시,부여남성(OR 6.51,95%CI 1.76～24.11,P=0.005)급HBV복제(OR 7.22,95%CI 1.68～30.97,P=0.008)상관.결론 남성、HBV복제、간경화급ALT승고도가능시HBV-GN적역환인소.여HBV-IgAN비교,경전형HBV-GN여병독복제급남성경상관,량자가능유불동적병리궤제.
Objective To retrospectively evaluate the relevant factors for hepatitis B virus-associated glomerulonephritis (HBV-GN).Methods A total of 86 patients with pathologyproven HBV-GN and 135 HBV carriers with non-HBV-GN were included in this retrospective casecontrol study.Logistic regression analysis was used to detect the relevant factors for HBV-GN.Results On univariate analysis,the factors associated with HBV-GN were as follows: male (OR 2.79,95%CI 1.48-5.25,P=0.001),HBeAg positivity (OR 2.60,95%CI 1.49-4.53,P=0.001),HBV replication (OR 3.63,95%CI 1.80-7.33,P＜0.01),liver cirrhosis (OR 4.58,95%CI 1.41-14.91,P=0.011),and elevated alanine aminotransferase (ALT) (OR 2.53,95%CI 1.42-4.51,P=0.002).On multivariate analysis,the associations remained significant for male (OR 2.21,95%CI 1.12-4.33,P=0.022),HBV replication (OR 2.77,95%CI 1.28-5.97,P=0.01),liver cirrhosis (0R 4.55,95%CI 1.29-16.10,P=0.019) and elevated ALT (OR 1.96,95%CI 1.04-3.69,P=0.037).Compared with HBV-associated IgA nephritis (HBV-IgAN) in multivariate model,HBV-associated membranous nephropathy (HBV-MN) or membranoproliferative glomerulonephritis (HBV-MPGN) was significantly associated with male (OR 6.51,95%CI 1.76-24.11,P=0.005) and HBV replication (OR 7.22,95%CI 1.68-30.97,P=0.008).Conclusions Male,HBV replication,liver cirrhosis and elevated ALT may be predictive factors for HBV-GN.Compared with HBV-IgAN,HBV-MN or HBV-MPGN is significantly associated with male and HBV replication.
