CAJ | 학술논문

目的探讨厄贝沙坦的降压疗效及对维吾尔族老年高血压患者左心室肥厚和舒张功能的影响.方法对130例1～2级原发性老年高血压患者给予口服厄贝沙坦150～300 mg治疗6个月周,观察治疗前后血压及心率变化.用M型超声心动图测量治疗前后舒张末期左心室内径(LVDd)、室间隔厚度(IVSD)、左室后壁厚度(LVPWD).采用多普勒超声心动图观察二尖瓣口舒张早期峰值速度(E)、舒张晚期峰值速度(A)及E峰减速时间(DT),计算E/A比值.结果患者治疗12周后各项指标与治疗前比较,血压明显下降(P＜0.05),E明显升高、A明显降低(P＜0.05),E/A值明显升高(P＜0.05).LVID、IVST、LVPWT、LVMI较治疗前明显减轻(P＜0.05).结论厄贝沙坦可显著降低血压,改善老年原发性高血压左心室肥厚和舒张功能.
목적 탐토액패사탄적강압료효급대유오이족노년고혈압환자좌심실비후화서장공능적영향.방법 대130례1～2급원발성노년고혈압환자급여구복액패사탄150～300 mg치료6개월주,관찰치료전후혈압급심솔변화.용M형초성심동도측량치료전후서장말기좌심실내경(LVDd)、실간격후도(IVSD)、좌실후벽후도(LVPWD).채용다보륵초성심동도관찰이첨판구서장조기봉치속도(E)、서장만기봉치속도(A)급E봉감속시간(DT),계산E/A비치.결과 환자치료12주후각항지표여치료전비교,혈압명현하강(P＜0.05),E명현승고、A명현강저(P＜0.05),E/A치명현승고(P＜0.05).LVID、IVST、LVPWT、LVMI교치료전명현감경(P＜0.05).결론 액패사탄가현저강저혈압,개선노년원발성고혈압좌심실비후화서장공능.
Objective To investigate the influences of Irbesartan on left ventricular hypertrophy and diastolic function in aged uygur patients with essential hypertension. Methods One hundred and thirty patients with 1-2stage essential hypertension were given Irbesartan 100 ～300 mg/d for twenty-four weeks. The change of blood pressure and heart beat before and after treatment was observed. The index of left ventricular end diastolic dimension ( LVDd), interventricular septal diameter ( IVSD ), left ventricular posterior wall diameter ( LVPWD )which reflecting the left ventricular hypertrophy were measured by M-mode ultrasound cardiography. Doppler echocardiographic recordings of flow velocity were obtained. Peak velocity in early diastole (E)and at atrial contraction(A) and mitral valve E-peak deceleration time were measured. E/A was calculated. Results After the treatment of Irbesartan for 12 weeks, blood pressure degraded,VA decreased significantly(P ＜ 0. 05 ),whereas VE and E/A increased significantly ( P ＜ 0. 05 ). LVID 、 IVST, LVPWT and LVMI decreased obviously ( P ＜0.05 ). Conclusion Irbesartan can obviously degrade the blood pressure and may significantly reverse left ventricular hypertrophy, improve the left ventricular diastolic function in super aged hypertensive patients.