CAJ | 학술논문

目的探讨溃疡性结肠炎(UC)患者外周血C-反应蛋白(CRP)和P-选择素(P-sel)的检测及临床意义.方法检测53例UC患者及35例健康对照组CRP和P-sel水平,分析两者对临床病情程度的影响.结果活动组患者CRP和P-sel水平明显高于缓解组和对照组(P＜0.05);重度组和中度组明显高于轻度组(P＜0.05,P＜0.01),重度组CRP水平明显高于中度组(P＜0.05);活动期UC患者CRP与P-sel水平呈正相关(r=0.638,P＜0.01).结论 CRP和P-sel与UC的发病及病情严重程度相关.
목적 탐토궤양성결장염(UC)환자외주혈C-반응단백(CRP)화P-선택소(P-sel)적검측급림상의의.방법 검측53례UC환자급35례건강대조조CRP화P-sel수평,분석량자대림상병정정도적영향.결과 활동조환자CRP화P-sel수평명현고우완해조화대조조(P＜0.05);중도조화중도조명현고우경도조(P＜0.05,P＜0.01),중도조CRP수평명현고우중도조(P＜0.05);활동기UC환자CRP여P-sel수평정정상관(r=0.638,P＜0.01).결론 CRP화P-sel여UC적발병급병정엄중정도상관.
Objective To study the detection and clinical signitlcanee of C reactivn protein(ClIP)and P-seleetin(P-sel)in patients with ulcerative colitis(UC).Methods The levels of peripheral blood ClIP and P-sel in patients with UC(n=53)and normal control group(n=35)were detected and the effects on disease severity were analyzed subsequently.Results The levels of blood CRP and P-sel in active phase group were significantly higher than those in catabasis group and normal controls group(P＜0.05);severe stage and medium stage were signiticandy higher than those in mild stage(P＜0.05,P＜0.01),severe stage was significantly higher than those in medium stage(P＜0.05);the blood level of CRP was positively related to P-sel in active phase group(r=0.638,P＜0.01).Conclusion CRP and P-sel were correlated with invasion and severity of UC.