CAJ | 학술논문

结直肠癌是胃肠道常见的恶性肿瘤之一,预后较差.大多数结直肠癌在早期即发生淋巴转移,在具备手术条件的患者中淋巴结转移率达50%.因而对直肠癌淋巴转移的机制进行研究是提高结直肠癌治疗效果的关键所在.以往由于缺乏特异性淋巴管标记物使得肿瘤淋巴转移的研究相对滞后,目前肿瘤淋巴管生成是肿瘤转移播散的研究热点,有关肿瘤中是否存在新生淋巴管以及淋巴管生成在肿瘤转移播散中的作用机制已经进行了大量研究,而对有关结直肠癌中淋巴管生成的研究也进行了有益的探索.本文旨在对特异性淋巴管内皮标记物、淋巴管生成因子、与结直肠癌中淋巴管生成有关的研究进展以及结直肠癌抗淋巴管生成治疗的可能前景与治疗策略进行综述.
결직장암시위장도상견적악성종류지일,예후교차.대다수결직장암재조기즉발생림파전이,재구비수술조건적환자중림파결전이솔체50%.인이대직장암림파전이적궤제진행연구시제고결직장암치료효과적관건소재.이왕유우결핍특이성림파관표기물사득종류림파전이적연구상대체후,목전종류림파관생성시종류전이파산적연구열점,유관종류중시부존재신생림파관이급림파관생성재종류전이파산중적작용궤제이경진행료대량연구,이대유관결직장암중림파관생성적연구야진행료유익적탐색.본문지재대특이성림파관내피표기물、림파관생성인자、여결직장암중림파관생성유관적연구진전이급결직장암항림파관생성치료적가능전경여치료책략진행종술.
Metastasis is the essential character of biological behaviors in malignancies,which is also the main reason for the death of patients with tumor. So it is very important to research the metastasis for the pre-vention and treatment of carcinomas. Rectal cancer is one of the most common gastrointestinal cancer,and its prognosis is bad. lymphatic metastasis is one important factor in the determination of colon cancer' s progno-sis. More than 50% patients are found lymphatic metastasis when taking operation. The ralationship of lym-phatic metastasis and prognosis is more important than the original tumor's invasiving. So it is meaningful to study the mechanism of tumor metastasis, and to provide a scientific approach to the prediction of tumor me-tastasis, the precise assessment of prognosis and the treatment of tumor metastasis.