国际麻醉学与复苏杂志
國際痳醉學與複囌雜誌
국제마취학여복소잡지
INTERNATIONAL JOURNAL OF ANESTHESIOLOGY AND RESUSCITATION
2012年
7期
470-473
,共4页
信号转导和转录激活因子3%神经发育%神经再生
信號轉導和轉錄激活因子3%神經髮育%神經再生
신호전도화전록격활인자3%신경발육%신경재생
Signal transducers and activators of transcription 3%Neurodevelopment%Neuroregeneration
背景 信号转导和转录激活因子(signal transducers and activators of transcription,STAT)3是一种存在于中枢和外周神经系统中调节广泛生物作用的转录因子,是信号转导和转录激活因子家族的7个成员之一.目的 对STAT3在神经发育和神经损伤后再生中的作用和可能的机制作一综述.内容 STAT3经由神经损伤释放出的多种细胞因子、自由基、炎症调节物活化,转录入核诱导相应的靶基因,提供神经保护作用.趋势 STAT3有望成为今后治疗神经缺血损伤和神经病理性疼痛新的治疗靶点.
揹景 信號轉導和轉錄激活因子(signal transducers and activators of transcription,STAT)3是一種存在于中樞和外週神經繫統中調節廣汎生物作用的轉錄因子,是信號轉導和轉錄激活因子傢族的7箇成員之一.目的 對STAT3在神經髮育和神經損傷後再生中的作用和可能的機製作一綜述.內容 STAT3經由神經損傷釋放齣的多種細胞因子、自由基、炎癥調節物活化,轉錄入覈誘導相應的靶基因,提供神經保護作用.趨勢 STAT3有望成為今後治療神經缺血損傷和神經病理性疼痛新的治療靶點.
배경 신호전도화전록격활인자(signal transducers and activators of transcription,STAT)3시일충존재우중추화외주신경계통중조절엄범생물작용적전록인자,시신호전도화전록격활인자가족적7개성원지일.목적 대STAT3재신경발육화신경손상후재생중적작용화가능적궤제작일종술.내용 STAT3경유신경손상석방출적다충세포인자、자유기、염증조절물활화,전록입핵유도상응적파기인,제공신경보호작용.추세 STAT3유망성위금후치료신경결혈손상화신경병이성동통신적치료파점.
Background Signal transducers and activators of transcription 3 (STAT3) is one of the seven members of the STATs family and mediates a wide variety of biological functions in the central and peripheral nervous systems.Objective To provide a review about the role and the possible mechanisms of STAT3 in neuronal development and regeneration.Content STAT3 is activated in response to the multiple cytokines,free radicals and other inflammatory mediator that are produced in damaged neural tissue.Activated STAT3 translocates to the nucleus,binds to the specific promoters of target genes,and induces gene expression,leads to neuroprotection.Trend Defining the endogenous molecular mechanisms that lead to neuroprotection by STAT3 after injury might identify novel therapeutic targets against neural tissue ischemic damage and neuropathic pain.
