中国医药
中國醫藥
중국의약
CHINA MEDICINE
2010年
6期
557-558
,共2页
异氟醚%顺式阿曲库铵%神经肌肉阻滞
異氟醚%順式阿麯庫銨%神經肌肉阻滯
이불미%순식아곡고안%신경기육조체
Isoflurane%Cisatracurium%Neuromuscular blockade
目的 观察异氟醚对老年患者顺式阿曲库铵肌肉松弛效应的影响.方法 60 例美国麻醉医师协会Ⅱ级行择期手术的老年患者,随机数字表法分为两组,每组30例.丙泊酚组持续输注丙泊酚4～6 mg/(kg·h),依据需要静注芬太尼维持麻醉;异氟醚组1.0 MAC异氟醚吸入,依据需要静注芬太尼维持麻醉.记录肌松起效时间、作用时间、术中维持速率、T1 25%、75%恢复时间、TOF比值恢复到70%的时间及恢复指数.结果 异氟醚组起效时间[(231.32±25.48)s]及恢复指数[(14.83±3.42)min]与丙泊酚组[(237.41±31.33)s、(13.07±3,74)min]差异无统计学意义,异氟醚组作用时间[(42.37±5.32)min]、T1 25%、75%恢复时间[(53.94±8.20)min、(70.78±7.65)min],明显长于丙泊酚组[(29.46±4.73)min、(41.31±6.43)min、(55.74±6.19)min,P＜0.05],异氟醚组术中维持速率[(88.32±13.25)μg/(kg·h)],明显小于丙泊酚组[(115.64±17.52)μg/(kg·h)].结论 异氟醚能显著延长老年患者顺式阿曲库铵的作用时间及恢复时间,减小术中维持速率,但对恢复指数无明显影响.
目的 觀察異氟醚對老年患者順式阿麯庫銨肌肉鬆弛效應的影響.方法 60 例美國痳醉醫師協會Ⅱ級行擇期手術的老年患者,隨機數字錶法分為兩組,每組30例.丙泊酚組持續輸註丙泊酚4～6 mg/(kg·h),依據需要靜註芬太尼維持痳醉;異氟醚組1.0 MAC異氟醚吸入,依據需要靜註芬太尼維持痳醉.記錄肌鬆起效時間、作用時間、術中維持速率、T1 25%、75%恢複時間、TOF比值恢複到70%的時間及恢複指數.結果 異氟醚組起效時間[(231.32±25.48)s]及恢複指數[(14.83±3.42)min]與丙泊酚組[(237.41±31.33)s、(13.07±3,74)min]差異無統計學意義,異氟醚組作用時間[(42.37±5.32)min]、T1 25%、75%恢複時間[(53.94±8.20)min、(70.78±7.65)min],明顯長于丙泊酚組[(29.46±4.73)min、(41.31±6.43)min、(55.74±6.19)min,P＜0.05],異氟醚組術中維持速率[(88.32±13.25)μg/(kg·h)],明顯小于丙泊酚組[(115.64±17.52)μg/(kg·h)].結論 異氟醚能顯著延長老年患者順式阿麯庫銨的作用時間及恢複時間,減小術中維持速率,但對恢複指數無明顯影響.
목적 관찰이불미대노년환자순식아곡고안기육송이효응적영향.방법 60 례미국마취의사협회Ⅱ급행택기수술적노년환자,수궤수자표법분위량조,매조30례.병박분조지속수주병박분4～6 mg/(kg·h),의거수요정주분태니유지마취;이불미조1.0 MAC이불미흡입,의거수요정주분태니유지마취.기록기송기효시간、작용시간、술중유지속솔、T1 25%、75%회복시간、TOF비치회복도70%적시간급회복지수.결과 이불미조기효시간[(231.32±25.48)s]급회복지수[(14.83±3.42)min]여병박분조[(237.41±31.33)s、(13.07±3,74)min]차이무통계학의의,이불미조작용시간[(42.37±5.32)min]、T1 25%、75%회복시간[(53.94±8.20)min、(70.78±7.65)min],명현장우병박분조[(29.46±4.73)min、(41.31±6.43)min、(55.74±6.19)min,P＜0.05],이불미조술중유지속솔[(88.32±13.25)μg/(kg·h)],명현소우병박분조[(115.64±17.52)μg/(kg·h)].결론 이불미능현저연장노년환자순식아곡고안적작용시간급회복시간,감소술중유지속솔,단대회복지수무명현영향.
Objective To investigate the effects of 1.0 MAC isoflurane on neuromuscular blockade by cisatracurium in old patients.Methods Sixty patients(ASA Ⅱ) aged 65-88, undergoing selective surgery under gener(group Ⅰ) , 1.0 MAC isoflurane(group Ⅱ) , with continuous neuromuscular blockade by cisatracurium.Neuromuscular blocking effects were monitored with an accelerometer.All patients were given fentanyl intermittently to maintain a relatively stable hemodynamie.The onset time, clinical duration, maintenance dose and times to T1 recovered to 25%, 75% and TOF ratio 70% were noted.The recovery index (time of T1 recovers from 25% to 75%) was also calculated.Results The clinical duration of group Ⅰ and group Ⅱ were(29.46 ±4.73)min and T1 25% 75% recovery time also showed difference between two groups(P ＜ 0.05).But there was no significant difference between two groups in onset time and recovery index.Conclusion 1.0 MAC isoflurane augments and prolongs the neuromuscular block produced by eisatraeurium in old patients, but does not effect the recovery index and the infusion rates.
