CAJ | 학술논문

目的探讨高压氧治疗老年2型糖尿病并存脑梗死患者神经心理障碍的有效性. 方法将70例入选患者随机分为治疗组和对照组,治疗组在常规药物治疗基础上联合10次高压氧治疗.选用老年成套心理测验,对所有患者治疗前后进行测试. 结果对照组患者神经心理障碍得到部分改善,治疗组患者改善程度明显提高(P<0.01).Spearman相关分析显示,神经心理障碍改善程度与高压氧治疗(r=0.502)、治疗前(r=0.260)和治疗后测验时间(r=0.386)呈正相关(P<0.05);与高脂血症(r=-0.261)、糖化血红蛋白(r=-0.321)和体质指数(r=-0.360)呈负相关(P<0.05).多元逐步同归分析显示,高压氧治疗和高脂血症是影响神经心理障碍改善程度独立的危险因素. 结论高压氧治疗有效,可作为老年2型糖尿病并存脑梗死患者神经心理障碍的治疗措施之一.
목적 탐토고압양치료노년2형당뇨병병존뇌경사환자신경심리장애적유효성. 방법 장70례입선환자수궤분위치료조화대조조,치료조재상규약물치료기출상연합10차고압양치료.선용노년성투심리측험,대소유환자치료전후진행측시. 결과 대조조환자신경심리장애득도부분개선,치료조환자개선정도명현제고(P<0.01).Spearman상관분석현시,신경심리장애개선정도여고압양치료(r=0.502)、치료전(r=0.260)화치료후측험시간(r=0.386)정정상관(P<0.05);여고지혈증(r=-0.261)、당화혈홍단백(r=-0.321)화체질지수(r=-0.360)정부상관(P<0.05).다원축보동귀분석현시,고압양치료화고지혈증시영향신경심리장애개선정도독립적위험인소. 결론 고압양치료유효,가작위노년2형당뇨병병존뇌경사환자신경심리장애적치료조시지일.
Objective To explore the therapeutic effect of hyperbaric oxygen therapy (HBO) in the treatment of neuropsychological disorders in senile patients with type 2 diabetes mellitus combined with cerebral infarction. Methods A total of 70 senile patients with type 2 diabetes mellitus combined with cerebral infarction were randomly divided into two groups: treatment group receiving HBO plus routine medicine treatment and control group receiving routing medicine treatment only. A suit of senile neuropsychological tests was administered pre and post treatment by an experienced psychometrician who was blinded to treatment group assignments. Results Neuropsychological disorders were improved partly in control group while the efficacy in treatment group was markedly improved(P<0.01). Spearman rank correlation analysis revealed that the improvement degree of neuropsychological disorders was positively correlated with hyperbaric oxygen therapy (HBO) (r= 0.502,P<0.05), the time of test before therapy (r=0.260, P<0.05) and the time of test after therapy (r=0.386, P<0.05), and was negatively correlated with hyperlipoidemia (r=-0.261, P< 0.05), glycosylated hemoglobin(GHbAlc) (r=-0.321,P<0.05) and body mass index(BMI) (r= 0.360,P<0.05). Multiple stepwise regression analysis showed that HBO and hyperlipoidemia were the independent predictors for the improvement degree of neuropsychological disorders. Conclusions HBO is an efficacious way to treat neuropsychological disorders in senile patients with type 2 diabetes mellitus combined with cerebral infarction.