中国小儿急救医学
中國小兒急救醫學
중국소인급구의학
CHINESE PEDIATRIC EMERGENCY MEDICINE
2011年
3期
237-239
,共3页
尿视黄醇结合蛋白%尿N-乙酰-β葡萄糖苷酶%窒息%早产儿
尿視黃醇結閤蛋白%尿N-乙酰-β葡萄糖苷酶%窒息%早產兒
뇨시황순결합단백%뇨N-을선-β포도당감매%질식%조산인
Urinary retinol binding protein%Urinary N-acetyl-β-glucosaminidase%Asphyxia%Infant,preterm
目的 分析尿视黄醇结合蛋白(RBP)、尿N-乙酰-β葡萄糖苷酶(NAG)对评价早产儿肾功能的临床意义.方法 受选新生儿89例,分为早产儿窒息组(18例)、早产儿非窒息组(25例)和足月儿对照组(46例).观察所选对象生后48h内晨尿的RBP和NAG水平,分别与尿肌酐(Cr)相比(以RBP/Cr和NAG/Cr表示);观察血肌酐和血尿素氮,以及非窒息早产儿在生后0~48h,~96h,~168h的RBP/Cr、NAG/Cr变化情况.结果 早产儿窒息组的尿RBP/Cr水平[(0.951±0.629)g/mol]高于非窒息组[(0.389±0.281)g/mol]和足月儿对照组[(0.119±0.081)g/mol],3组间比较差异有统计学意义(P<0.05);非窒息组高于足月儿对照组(P<0.05).早产儿窒息组和非窒息组的尿NAG/Cr比值均高于足月儿对照组,差异有统计学意义(P<0.05),但前两者比较差异无统计学意义(P>0.05).3组间的血肌酐和尿素氮比较差异无统计学意义(P>0.05).早产儿非窒息组尿RBP/Cr与胎龄和日龄均无线性相关(P>0.05),而NAG/Cr与胎龄呈线性负相关(r=-0.625,P<0.05),与日龄呈正相关(P<0.05).结论 尿RBP/Cr和NAG/Cr比值有助于评估早产儿肾功能,前者对窒息损害较后者敏感,后者受胎龄影响更大.
目的 分析尿視黃醇結閤蛋白(RBP)、尿N-乙酰-β葡萄糖苷酶(NAG)對評價早產兒腎功能的臨床意義.方法 受選新生兒89例,分為早產兒窒息組(18例)、早產兒非窒息組(25例)和足月兒對照組(46例).觀察所選對象生後48h內晨尿的RBP和NAG水平,分彆與尿肌酐(Cr)相比(以RBP/Cr和NAG/Cr錶示);觀察血肌酐和血尿素氮,以及非窒息早產兒在生後0~48h,~96h,~168h的RBP/Cr、NAG/Cr變化情況.結果 早產兒窒息組的尿RBP/Cr水平[(0.951±0.629)g/mol]高于非窒息組[(0.389±0.281)g/mol]和足月兒對照組[(0.119±0.081)g/mol],3組間比較差異有統計學意義(P<0.05);非窒息組高于足月兒對照組(P<0.05).早產兒窒息組和非窒息組的尿NAG/Cr比值均高于足月兒對照組,差異有統計學意義(P<0.05),但前兩者比較差異無統計學意義(P>0.05).3組間的血肌酐和尿素氮比較差異無統計學意義(P>0.05).早產兒非窒息組尿RBP/Cr與胎齡和日齡均無線性相關(P>0.05),而NAG/Cr與胎齡呈線性負相關(r=-0.625,P<0.05),與日齡呈正相關(P<0.05).結論 尿RBP/Cr和NAG/Cr比值有助于評估早產兒腎功能,前者對窒息損害較後者敏感,後者受胎齡影響更大.
목적 분석뇨시황순결합단백(RBP)、뇨N-을선-β포도당감매(NAG)대평개조산인신공능적림상의의.방법 수선신생인89례,분위조산인질식조(18례)、조산인비질식조(25례)화족월인대조조(46례).관찰소선대상생후48h내신뇨적RBP화NAG수평,분별여뇨기항(Cr)상비(이RBP/Cr화NAG/Cr표시);관찰혈기항화혈뇨소담,이급비질식조산인재생후0~48h,~96h,~168h적RBP/Cr、NAG/Cr변화정황.결과 조산인질식조적뇨RBP/Cr수평[(0.951±0.629)g/mol]고우비질식조[(0.389±0.281)g/mol]화족월인대조조[(0.119±0.081)g/mol],3조간비교차이유통계학의의(P<0.05);비질식조고우족월인대조조(P<0.05).조산인질식조화비질식조적뇨NAG/Cr비치균고우족월인대조조,차이유통계학의의(P<0.05),단전량자비교차이무통계학의의(P>0.05).3조간적혈기항화뇨소담비교차이무통계학의의(P>0.05).조산인비질식조뇨RBP/Cr여태령화일령균무선성상관(P>0.05),이NAG/Cr여태령정선성부상관(r=-0.625,P<0.05),여일령정정상관(P<0.05).결론 뇨RBP/Cr화NAG/Cr비치유조우평고조산인신공능,전자대질식손해교후자민감,후자수태령영향경대.
Objective To investigate the clinical value of urinary retinol binding protein(RBP) and N-acetyl-β-glucosaminidase(NAG) for evaluating renal function in preterm neonate.Methods 89 neonates in our NICU were selected,divided into three groups:the asphyxial preterm group (18 cases),the no-asphxial preterm group (25 cases),and the control group (46 term infants without asphyxia).All objects were detected the urinary RBP,NAG and creatinine(Cr).The levels of RBP/Cr and NAG/Cr and blood urea nitrogen(BUN),Cr were observed within 48h after birth after birth.The fluctuations of urinary RBP/Cr and NAG/Cr in no-asphxial preterm group also were observed in 0~48h,~96h,~168h after birth respectively.Results The urinary RBP/Cr levels in asphyxial preterm group [(0.951±0.629)g/mol] were higher than those in no-asphxial preterm group[(0.389±0.281)g/mol] and the control group[(0.119±0.081)g/mol](P<0.05).The urinary RBP/Cr levels in no-asphxial preterm group were also significantly higher than those in the control group(P<0.05).The levels of urinary NAG/Cr in the asphyxial and no-asphxial preterm groups were both higher than those in the control group(P<0.05),but there was no difference betwteen the former two groups(P>0.05).The levels of serum Cr and BUN were no significant difference in the three groups(P>0.05).The urinary RBP/Cr level had non-linear correlation with either postnatal or gestational age in no-asphyxial preterm group.While the urinary NAG/Cr levels negative correlated with the gestational age(r=-0.625,P<0.05).And the correlation between the urinary NAG/Cr and postnatal age was postive(P<0.05).Conclusion The determination of urinary NAG/Cr and RBP/Cr provides a sensitive and reliable method to evaluate the renal function of neonates,especially in preterm infants.The RBP/Cr is affected by asphyxia more than NAG/Cr,which is rather correlated with gestational age.
