国际麻醉学与复苏杂志
國際痳醉學與複囌雜誌
국제마취학여복소잡지
INTERNATIONAL JOURNAL OF ANESTHESIOLOGY AND RESUSCITATION
2011年
4期
398-400
,共3页
伤害性刺激%定量药物脑电图%α2频段%镇痛
傷害性刺激%定量藥物腦電圖%α2頻段%鎮痛
상해성자격%정량약물뇌전도%α2빈단%진통
Nociceptive stimulation%Quantitative pharmaco-EEG%α2-rhythm%Analgesia
目的观察伤害性刺激对家兔定量药物脑电图(quaxtutative pharnaco-EEG，QPEEG)α2频段的影响。 方法壮年家兔，雌雄不拘，利用随机排列表，将实验动物随机分为擦拭组、钳夹组、切皮组，每组9只。经耳缘静脉注射肌松剂，建立肌松兔模型，在此模型上分别给予棉球擦拭、钳夹兔耳缘、做腹正中腹膜外切口3种刺激。应用QPEEG，采用功率谱分析技术，观察刺激前30 s及刺激后30 s、1、2、5、10 min的兔脑α2频段功率百分比的变化。结果与刺激前相比，棉球擦拭组α2频段功率百分比无明显改变(P＞0.05)；钳夹组α2频段功率百分比在钳夹后的30 s～1 min内升高(P＜0.05)，其中左颞区刺激前为(6.0±1.8)％，刺激后为(10.0±3.0)％；；切皮组在切皮后30 s～2 min内，各脑区α2频段功率百分比均明显升高(P＜0.05)，左颞区刺激前为(5.3±2.0)％，刺激后为(13.0±5.0)％。结论伤害性刺激引起兔QPEEGα2频段功率百分比升高，提示α2频段功率百分比有可能成为反映镇痛程度的指标。
目的觀察傷害性刺激對傢兔定量藥物腦電圖(quaxtutative pharnaco-EEG，QPEEG)α2頻段的影響。 方法壯年傢兔，雌雄不拘，利用隨機排列錶，將實驗動物隨機分為抆拭組、鉗夾組、切皮組，每組9隻。經耳緣靜脈註射肌鬆劑，建立肌鬆兔模型，在此模型上分彆給予棉毬抆拭、鉗夾兔耳緣、做腹正中腹膜外切口3種刺激。應用QPEEG，採用功率譜分析技術，觀察刺激前30 s及刺激後30 s、1、2、5、10 min的兔腦α2頻段功率百分比的變化。結果與刺激前相比，棉毬抆拭組α2頻段功率百分比無明顯改變(P＞0.05)；鉗夾組α2頻段功率百分比在鉗夾後的30 s～1 min內升高(P＜0.05)，其中左顳區刺激前為(6.0±1.8)％，刺激後為(10.0±3.0)％；；切皮組在切皮後30 s～2 min內，各腦區α2頻段功率百分比均明顯升高(P＜0.05)，左顳區刺激前為(5.3±2.0)％，刺激後為(13.0±5.0)％。結論傷害性刺激引起兔QPEEGα2頻段功率百分比升高，提示α2頻段功率百分比有可能成為反映鎮痛程度的指標。
목적관찰상해성자격대가토정량약물뇌전도(quaxtutative pharnaco-EEG，QPEEG)α2빈단적영향。 방법장년가토，자웅불구，이용수궤배렬표，장실험동물수궤분위찰식조、겸협조、절피조，매조9지。경이연정맥주사기송제，건립기송토모형，재차모형상분별급여면구찰식、겸협토이연、주복정중복막외절구3충자격。응용QPEEG，채용공솔보분석기술，관찰자격전30 s급자격후30 s、1、2、5、10 min적토뇌α2빈단공솔백분비적변화。결과여자격전상비，면구찰식조α2빈단공솔백분비무명현개변(P＞0.05)；겸협조α2빈단공솔백분비재겸협후적30 s～1 min내승고(P＜0.05)，기중좌섭구자격전위(6.0±1.8)％，자격후위(10.0±3.0)％；；절피조재절피후30 s～2 min내，각뇌구α2빈단공솔백분비균명현승고(P＜0.05)，좌섭구자격전위(5.3±2.0)％，자격후위(13.0±5.0)％。결론상해성자격인기토QPEEGα2빈단공솔백분비승고，제시α2빈단공솔백분비유가능성위반영진통정도적지표。
Objective To study the effects of nocuous stimulation on α2-band of quantitative pharmaco-EEG (QPEEG) in rabbits. Methods Rabbits of both sexes were randomly divided into 3 groups (n=9): mopping group (group M), forceps holder group (group H), cutting group (group C). The animal model was established by muscle relaxant administered intravenously to the anesthetized rabbit. Then different stimulation was given to the rabbits: mopping stimulation was given in group M, ears holding by forceps was given in group H, belly cut was given in group C. The EEG sample was obtained before 30 s and 30 s, 1, 2, 5, 10 min following the stimulation was given. The EEG activity was processed with the power spectral analysis. Results The percentage of α2-band power showed no significant changes in group M(P＞0.05); while was increased(P＜0.05) in group H within 30 s-1 min after received stimulation in all the areas. However, the percentage of α2-band power in group C increased significantly in all areas of brain for 2 min (P＜0.05). Conclusion After given nocuous stimulation, the percentage of α2-band power increased, which indicated that the percentage of α2-band power would be an effective means of monitoring pain.
