CAJ | 학술논문

目的探讨噻托溴铵与沙美特罗/氟替卡松联合应用对中度COPD患者肺功能及生命质量的影响.方法将60例中度COPD患者随机分为A、B、C三组,A组单用噻托溴铵,B组单用沙美特罗/氟替卡松,C组同时使用噻托溴铵和沙美特罗/氟替卡松,治疗3个月,检测治疗前后肺功能及生命质量评分.结果 A组及B组治疗前后FEV1/FVC改善具有显著的统计学意义,但两组FEV1的改善无统计意义,而C组FEV1及FEV1/FVC治疗前后改善均具有显著统计学意义;A组治疗前后生命质量总均分差异无统计学意义,而B组及C组治疗前后生命质量总均分改善具有显著性统计学意义.结论联合吸入长效抗胆碱能药物、长效β-2受体激动剂及糖皮质激素不仅能改善中度COPD患者肺功能,同时能提高生命质量.
목적 탐토새탁추안여사미특라/불체잡송연합응용대중도COPD환자폐공능급생명질량적영향.방법 장60례중도COPD환자수궤분위A、B、C삼조,A조단용새탁추안,B조단용사미특라/불체잡송,C조동시사용새탁추안화사미특라/불체잡송,치료3개월,검측치료전후폐공능급생명질량평분.결과 A조급B조치료전후FEV1/FVC개선구유현저적통계학의의,단량조FEV1적개선무통계의의,이C조FEV1급FEV1/FVC치료전후개선균구유현저통계학의의;A조치료전후생명질량총균분차이무통계학의의,이B조급C조치료전후생명질량총균분개선구유현저성통계학의의.결론 연합흡입장효항담감능약물、장효β-2수체격동제급당피질격소불부능개선중도COPD환자폐공능,동시능제고생명질량.
Objective To investigate the effects of tiotropium with salmeterol / fluticasone in patients with moderate chronic obstructive pulmonary disease. Motbods 60 patients with stable moderate chronic obstructive pulmonary disease were randomly divided into 3 groups of tiotropium ( A group ),saimeterol/fluticasone ( B group ) and tiotropium +saimeterol/fluticasone ( C group ), FEV1, FEV1/FVC and quality of life(QOL) were measured before and 3 months after treatment. Results The FEV1/FVC in all groups was improved. Furthermore the EEV1 in C group was obviously improved. Except A group, the QOL in B and C groups were also obviously improved. Conelusion The joint usage of tiotropium and salmeterol/fluticasone in patients with moderate chronic obstructive pulmonary disease can improve the pulmonary function and quality of life.