CAJ | 학술논문

近来一项87例英国健康人群的影像遗传学研究,报告了DISC1 Ser704.Cys显著调控脑内的大范围的白质完整性.然而,此类研究的结果在独立样本中的可重复性尤其重要.我们用一组较大样本的健康中国汉族人群,同时采集了遗传学资料和弥散磁共振影像学数据,然后开展了同样的基于纤维束骨架的空间统计分析(TBSS分析)研究,然后在我们的样本中没有发现DISC1 Ser704Cys与白质完整性的任何显著性相关.我们的研究结果不支持在中国汉族人群中的DISC1 Ser704Cys与脑白质完整型的显著性关联.因此,此相关很有必要在更进一步独立样本中的验证.
근래일항87례영국건강인군적영상유전학연구,보고료DISC1 Ser704.Cys현저조공뇌내적대범위적백질완정성.연이,차류연구적결과재독립양본중적가중복성우기중요.아문용일조교대양본적건강중국한족인군,동시채집료유전학자료화미산자공진영상학수거,연후개전료동양적기우섬유속골가적공간통계분석(TBSS분석)연구,연후재아문적양본중몰유발현DISC1 Ser704Cys여백질완정성적임하현저성상관.아문적연구결과불지지재중국한족인군중적DISC1 Ser704Cys여뇌백질완정형적현저성관련.인차,차상관흔유필요재경진일보독립양본중적험증.
One recent study from a population of 87 healthy UK subjects has reported a significant association of white matter integrity with DISCI Ser704Cys. Such association is rather impressive, but replication studies in independent populations are necessary. With a large sample of 278 healthy Han Chinese subjects, we carried out the same analyses to test the association of white matter integrity with DISC Ser704Cys, but did not find any significant association. Our results do not support the association between white matter integrity measured by tract-based spatial statistics ( TBSS) method and DISCI Ser704Cys, at least in the Han Chinese population. More replication studies in different population are desired to further test the association.