CAJ | 학술논문

以6-氟-4-氯喹唑啉与反式-4-（2-芳基乙烯基）苯胺类化合物为原料,经胺化反应,合成了4-[4-（（E-）3,4,5-三甲氧基苯乙烯基）]苯氨基-6-氟喹唑啉等六种新型4-芳氨基-6-氟喹唑啉类衍生物,收率55%～76%,其结构利用1 H NMR,IR和元素分析进行确证.1 H NMR分析表明,化合物在δ9.74～9.79出现的单峰为4位的—NH所产生;IR谱图中,化合物在3 618～3 278cm-1出现一个吸收峰,同样证明了目标化合物的生成.
이6-불-4-록규서람여반식-4-（2-방기을희기）분알류화합물위원료,경알화반응,합성료4-[4-（（E-）3,4,5-삼갑양기분을희기）]분안기-6-불규서람등륙충신형4-방안기-6-불규서람류연생물,수솔55%～76%,기결구이용1 H NMR,IR화원소분석진행학증.1 H NMR분석표명,화합물재δ9.74～9.79출현적단봉위4위적—NH소산생;IR보도중,화합물재3 618～3 278cm-1출현일개흡수봉,동양증명료목표화합물적생성.
Six novel 4-arylamino-6-fluoroquinazolines such as 4-[4-（（E）-3,4,5-trimethoxystyryl）]anilino-6-fluoroquinazoline etc.were synthesized from 6-fluoro-4-chloroquinazoline and trans-aminostilbene derivatives in yields of 55%~76%.Their chemical structures were identified by 1H NMR,IR and elemental analysis.The 1H NMR analysis showed that the single peak in the δ 9.74~9.79 ppm was produced by the—NH of the 4-position in the compounds;The IR analysis showed that the peak in 3 618~3 278 cm-1 also proved the formation of the target compounds.