精细与专用化学品
精細與專用化學品
정세여전용화학품
FINE AND SPECIALTY CHEMICALS
2011年
9期
35-37
,共3页
赵桂连%曹魏%张申红%张军
趙桂連%曹魏%張申紅%張軍
조계련%조위%장신홍%장군
兰索拉唑%合成%新工艺
蘭索拉唑%閤成%新工藝
란색랍서%합성%신공예
lansoprazole%synthesis%new process
报道了以兰索拉唑羟基物（2-羟甲基3-甲基-4（2,2,2-三氟乙氧基）-吡啶）为起始原料进行兰索拉唑合成的新工艺。新工艺中用PBr3替代SOCl2作为卤化剂,用H2O2—（NH3）2MoO4体系替代间氯过氧苯甲酸作为氧化剂,卤化与缩合工艺合并成一步。试验结果表明,该新工艺操作简单,能有效降低生产成本,可满足工业化生产要求。
報道瞭以蘭索拉唑羥基物（2-羥甲基3-甲基-4（2,2,2-三氟乙氧基）-吡啶）為起始原料進行蘭索拉唑閤成的新工藝。新工藝中用PBr3替代SOCl2作為滷化劑,用H2O2—（NH3）2MoO4體繫替代間氯過氧苯甲痠作為氧化劑,滷化與縮閤工藝閤併成一步。試驗結果錶明,該新工藝操作簡單,能有效降低生產成本,可滿足工業化生產要求。
보도료이란색랍서간기물（2-간갑기3-갑기-4（2,2,2-삼불을양기）-필정）위기시원료진행란색랍서합성적신공예。신공예중용PBr3체대SOCl2작위서화제,용H2O2—（NH3）2MoO4체계체대간록과양분갑산작위양화제,서화여축합공예합병성일보。시험결과표명,해신공예조작간단,능유효강저생산성본,가만족공업화생산요구。
In this paper,a new synthetic process of lansoprazole was studied with 2-hydroxymethyl-3-methyl- 4-（2,2,2-trifluoroethoxy） pyridine as the original material.In new process,the PBr3 was selected as halogenating agent instead of SOCl2 and the H2O2—（NH3）2MoO4 system was selected as oxidant instead of 3-chloroperoxybenzoic acid,the halogenation and condensation processes were merged into one step.The trial results showed that the new process is ease of clinical manipulation and can decreased the cost effectively and meets the requirement of manufacture.
