CAJ | 학술논문

采用微波辐照雄性清洁级Wistar大鼠，观察其对大鼠外周血淋巴细胞亚群的影响。实验结果显示：与对照组相比，10mW／cm2组、30mW／cm2组照射后第7天，5mW／cm2组、10mW／cm2组、30mW/cm2组照射后第14天，CD3＋降低显著；10mW/cm2组照射后第14天，CD4＋降低显著。各辐照组照射后第1、7、14天，CD8＋均降低，其中，30mW／cm2组降低显著；5mW／crn2组照射后第1天，5rdW／cm2组、30mW／cm2组照射后第14天，CD4＋／CD8＋比值降低显著。与T淋巴细胞变化趋势相反，与对照组相比，微波辐照后，各剂量照射组B淋巴细胞CD45RA＋均升高，其中，30mW/cm2照射后第1天，30mW／cm2组、60mW／cm2组照射后第14天，升高显著，并且在照射后第14天，CD45RA＋随照射剂量的升高而升高。结果提示，一定剂量的微波辐照能诱发大鼠外周血淋巴细胞亚群比例的改变，导致免疫功能受损。
채용미파복조웅성청길급Wistar대서，관찰기대대서외주혈림파세포아군적영향。실험결과현시：여대조조상비，10mW／cm2조、30mW／cm2조조사후제7천，5mW／cm2조、10mW／cm2조、30mW/cm2조조사후제14천，CD3＋강저현저；10mW/cm2조조사후제14천，CD4＋강저현저。각복조조조사후제1、7、14천，CD8＋균강저，기중，30mW／cm2조강저현저；5mW／crn2조조사후제1천，5rdW／cm2조、30mW／cm2조조사후제14천，CD4＋／CD8＋비치강저현저。여T림파세포변화추세상반，여대조조상비，미파복조후，각제량조사조B림파세포CD45RA＋균승고，기중，30mW/cm2조사후제1천，30mW／cm2조、60mW／cm2조조사후제14천，승고현저，병차재조사후제14천，CD45RA＋수조사제량적승고이승고。결과제시，일정제량적미파복조능유발대서외주혈림파세포아군비례적개변，도치면역공능수손。
CD3 ＋ cells in 10 - 30 mW/cm2 groups at 7 d and in 5 - 30 mW/cmz groups at 14 d and CD4＋ T subset in 10 roW/cm2 group at 14 d post radiation were all decreased signifieantiy as compared with control groups. 1 to 14 d after radiation, CD8＋ T cells in all irradiated groups showed reduction, however, only that in 30 mW/cm2 group reduced statistically when compared with control group. CIM＋/CD8＋ ratios in 5 mW/cm2 group at ld and in 5 - 30 mW/cm2 groups at 14 d post radiation were all diminished statistically as compared with control groups. After microwave exposure, CIM5RA＋ B cells showed opposite change to the T cells, for instance, CD45RA＋ B cells in 30 mW/emz group at 1 d and in 30 - 60 mW/cm2 groups at 14 d post radiation increased significantly, which showed better dose-effect relationship 14 d after irradiation.