CAJ | 학술논문

目的确定司来吉兰贴片的处方及研究方法。方法通过正交设计试验研究确定司来吉兰贴片各组分的含量。结果司来吉兰经皮给药系统的最佳处方组成为：主药量为3%,促渗剂选用氮酮,含量为3%,增塑剂含量为15%,压敏胶含量为60%。背衬材料为涂铝膜的聚酯膜。结论司来吉兰适合制成经皮给药系统。正交设计实验是研究司来吉兰贴片处方的有效方法。
목적학정사래길란첩편적처방급연구방법。방법통과정교설계시험연구학정사래길란첩편각조분적함량。결과사래길란경피급약계통적최가처방조성위：주약량위3%,촉삼제선용담동,함량위3%,증소제함량위15%,압민효함량위60%。배츤재료위도려막적취지막。결론사래길란괄합제성경피급약계통。정교설계실험시연구사래길란첩편처방적유효방법。
Objective To determine the prescription of selegiline transdermal patches.Methods The selegiline transdermal patches were prepared and the ingredient amount of selegiline transdermal patches was determined according to the orthogonal design.Results The best prescription of selegiline transdermal patches：3%selegiline,3%Azone,15%RS100,60%PSA.Conclusion Selegiline is suitable for the transdermal therapeutic systems.Orthogonal design of prescription was suitable to study selegiline transdermal patches.