CAJ | 학술논문

目的观察硫辛酸联合恩再适治疗抗肿瘤药物所致周围神经病变的疗效.方法将43例恶性肿瘤化疗后周围神经病变患者,给予硫辛酸 600 mg+恩再适7.2 U静脉滴注,1次/d,共2周.比较治疗前后患者临床症状和体征变化.结果治疗前后神经电生理检查,正中神经、腓总神经的神经传导速度(MCV)间差异均有统计学意义(P＜0.05);治疗前患者视觉模拟评分(VAS)为(5.2±2.5)分,治疗后为(1.9±1.2)分,治疗前后比较差异有统计学意义(P＜0.01);治疗后显效率为83.72 %,总有效率为95.34%.结论硫辛酸与恩再适联用可显著改善恶性肿瘤化疗后的周围神经症状.
목적 관찰류신산연합은재괄치료항종류약물소치주위신경병변적료효.방법 장43례악성종류화료후주위신경병변환자,급여류신산 600 mg+은재괄7.2 U정맥적주,1차/d,공2주.비교치료전후환자림상증상화체정변화.결과 치료전후신경전생리검사,정중신경、비총신경적신경전도속도(MCV)간차이균유통계학의의(P＜0.05);치료전환자시각모의평분(VAS)위(5.2±2.5)분,치료후위(1.9±1.2)분,치료전후비교차이유통계학의의(P＜0.01);치료후현효솔위83.72 %,총유효솔위95.34%.결론 류신산여은재괄련용가현저개선악성종류화료후적주위신경증상.
Objective To observe the clinical effect of Lipoic acid and Analgecine on peripheral neuropathy induced by anticancer drugs.Methods Forty-three patients with chemotherapy-induced peripheral neuropathy were given lipoic acid (600 mg) with intravenous infusion of analgecine (7.2 U),once a day,2 weeks.The changes of clinical symptoms and signs were compared between pre-and post-treatment.Results There was significant difference in MCV of median nerve and common peroneal between pre-and post-treatment (P＜0.05).The visual analogue scale (VSA) was (5.2±2.5) before treatment,and (1.9±1.2) after treatment,the difference was significant (P＜0.01).The posttreatment efficiency was 83.72%,total effective rate 95.34%.Conclusion Lipoic acid combined with analgecine can improve effectively the peripheral nerve symptoms after chemotherapy of malignant tumors.