CAJ | 학술논문

从统计学视角分析甲型流感病毒基质蛋白2(M2)的种属差异和亚型差异.首先,用氨基酸对的可预测性将1129个M2蛋白质转换成1129标量数据,然后用Ⅰ型ANOVA分析这些数据,寻找是否存在种属和亚型的区别,最后用Ⅱ型ANOVA确定组间和组内的差异,进一步追踪跨种属感染和跨亚型突变的原因.得到3条统计学证据,说明甲型流感病毒可能发生跨种属感染和跨亚型突变,其原因是由于各种属和亚型之间的屏障不够强壮,导致突变易于跨越到其它种属或亚型.
종통계학시각분석갑형류감병독기질단백2(M2)적충속차이화아형차이.수선,용안기산대적가예측성장1129개M2단백질전환성1129표량수거,연후용Ⅰ형ANOVA분석저사수거,심조시부존재충속화아형적구별,최후용Ⅱ형ANOVA학정조간화조내적차이,진일보추종과충속감염화과아형돌변적원인.득도3조통계학증거,설명갑형류감병독가능발생과충속감염화과아형돌변,기원인시유우각충속화아형지간적병장불구강장,도치돌변역우과월도기타충속혹아형.
The species and subtype differences were analyzed in the matrix 2 (M2) proteins of influenza A viruses from a statistical viewpoint. First,the amino-acid pair predictability was used to convert 1129 M2 proteins into 1129 scalar data;Second,the model Ⅰ ANOVA was used to analyze these data in terms of species and subtype in order to find if they are distinguishable; Third,the model Ⅱ ANOVA was used to determine the inter- and intra-species/subtype variations to further trace the reason for cross-species infection and cross-subtype mutation. The results provide three pieces of statistical evidence to demonstrate why the cross-species infection and cross-subtype mutation are possible because the barriers between species and between subtypes are not strong enough, which leads a mutation to easily jump to another species or subtype.